Table 1. Clinical and laboratory data of... | American Society of Hematology

Table 1.

Clinical and laboratory data of the patients studied

Patient no.	Age/ sex	Duration, mo	Peripheral blood^*		Neutro count, × 10⁹/L	Lympho count, × 10⁹/L	Mono count, × 10⁹/L	Plts count, × 10⁹/L	Bone marrow^*		PGP/MGP ratio^1-153	Erythroid, %	M/E ratio^1-155	Lympho, %	Plasma, %	Other, %
Patient no.	Age/ sex	Duration, mo	Hgb level, g/dL	WBC count, × 10⁹/L	Neutro count, × 10⁹/L	Lympho count, × 10⁹/L	Mono count, × 10⁹/L	Plts count, × 10⁹/L	PGP,^† %	MGP,^‡ %	PGP/MGP ratio^1-153	Erythroid, %	M/E ratio^1-155	Lympho, %	Plasma, %	Other, %
1	37/F	64	13.2	3.5	1.7	1.4	0.5	139	15.3	32.3	0.47	42.6	1.12	5.4	0.5	3.9
2	32/F	48	12.7	3.2	1.1	1.7	0.2	196	16.0	32.3	0.49	29.7	1.63	15.0	1.5	5.5
3	53/F	86	13.2	2.5	0.2	1.6	0.3	200	25.7	21.7	1.18	39.1	1.21	11.7	1.2	0.6
4	48/M	120	15.9	3.4	1.1	1.7	0.7	205	20.3	30.1	0.67	30.9	1.63	13.3	1.8	3.6
5	73/M	96	13.4	3.0	1.6	1.0	0.6	135	21.6	29.4	0.73	36.5	1.40	8.7	3.0	0.8
6	61/F	65	12.4	3.0	1.1	1.6	0.3	241	20.5	33.6	0.61	30.3	1.78	12.0	1.4	2.3
7	65/F	131	13.1	4.5	1.7	2.2	0.5	273	14.3	31.5	0.45	34.2	1.34	12.9	4.0	4.0
8	71/F	24	13.3	4.1	1.5	2.3	0.3	147	20.1	29.7	0.68	38.3	1.30	8.8	1.1	2.0
9	65/F	50	12.4	4.1	1.8	2.0	0.3	126	15.5	28.1	0.55	29.0	1.50	21.1	3.4	2.9
10	32/F	27	12.1	3.6	1.2	1.8	0.5	259	20.0	30.4	0.66	29.0	1.74	16.1	1.6	3.0
11	60/F	144	13.8	4.5	1.7	2.5	0.3	220	20.0	30.1	0.66	28.6	1.75	15.6	3.0	2.7
12	74/F	18	11.5	3.1	1.6	1.2	0.2	156	18.5	33.7	0.55	29.8	1.75	12.8	3.5	1.7
13	48/F	120	13.2	3.5	1.6	1.4	0.4	243	21.4	30.5	0.70	26.4	1.96	19.0	1.0	1.7
14	68/F	112	13.4	5.8	1.8	3.1	0.4	231	17.6	21.9	0.80	45.9	0.86	9.0	3.0	2.6
15	70/F	16	13.9	3.2	1.3	1.5	0.3	169	16.2	31.1	0.52	34.6	1.37	13.6	0.8	3.7
16	65/F	103	13.9	3.6	1.7	1.6	0.3	244	21.3	31.2	0.68	29.7	1.77	10.4	4.7	2.7
17	52/F	100	13.1	4.1	1.5	2.1	0.4	229	18.7	31.2	0.60	32.7	1.53	11.8	1.7	3.9
18	66/F	43	13.7	4.2	1.7	1.7	0.4	211	18.7	32.4	0.58	33.8	1.51	10.2	1.7	3.2
19	60/F	83	13.0	3.0	1.4	1.2	0.3	210	18.1	26.4	0.69	40.6	1.10	9.4	2.5	3.0
20	32/F	72	12.8	3.3	1.5	1.4	0.3	257	17.8	34.6	0.51	30.5	1.65	13.5	1.9	3.7
21	50/F	125	13.3	3.2	1.1	1.7	0.2	196	22.3	28.4	0.78	35.2	1.44	9.0	1.3	3.8
22	50/F	97	11.7	3.1	1.4	1.4	0.3	121	23.8	26.7	0.89	36.8	1.37	6.7	2.8	3.2
23	63/F	180	11.5	2.4	1.5	0.7	0.2	166	23.4	29.3	0.80	37.7	1.40	7.9	0.6	1.0
24	55/F	51	13.3	3.5	1.6	1.5	0.4	278	20.1	31.4	0.64	32.1	1.60	11.9	2.2	2.3
25	63/F	125	12.9	4.1	1.5	2.0	0.5	228	20.8	30.3	0.69	31.1	1.64	11.7	2.9	3.2
26	35/F	60	12.9	3.1	1.2	1.5	0.3	224	18.4	34.6	0.53	30.1	1.76	12.1	2.0	2.8
27	44/F	12	13.0	4.9	1.4	2.6	0.3	189	15.5	32.8	0.47	31.7	1.52	14.0	1.5	4.5
28	70/F	120	12.1	3.6	1.2	1.8	0.5	259	14.3	31.5	0.45	34.2	1.34	12.9	4.0	4.0
29	77/F	121	13.4	3.7	1.7	1.6	0.3	100	21.3	31.2	0.68	29.7	1.77	10.4	4.7	2.7
30	56/F	130	13.6	3.0	1.4	1.2	0.3	253	21.3	31.2	0.68	28.7	1.83	11.4	4.7	2.7
31	73/F	120	12.7	5.3	1.7	2.7	0.7	182	17.0	31.3	0.54	30.7	1.57	14.0	1.5	5.5
32	33/F	72	13.8	3.5	1.2	1.9	0.3	188	17.0	33.3	0.51	30.7	1.64	15.0	1.5	2.5

Patient no.	Age/ sex	Duration, mo	Peripheral blood^*		Neutro count, × 10⁹/L	Lympho count, × 10⁹/L	Mono count, × 10⁹/L	Plts count, × 10⁹/L	Bone marrow^*		PGP/MGP ratio^1-153	Erythroid, %	M/E ratio^1-155	Lympho, %	Plasma, %	Other, %
Patient no.	Age/ sex	Duration, mo	Hgb level, g/dL	WBC count, × 10⁹/L	Neutro count, × 10⁹/L	Lympho count, × 10⁹/L	Mono count, × 10⁹/L	Plts count, × 10⁹/L	PGP,^† %	MGP,^‡ %	PGP/MGP ratio^1-153	Erythroid, %	M/E ratio^1-155	Lympho, %	Plasma, %	Other, %
1	37/F	64	13.2	3.5	1.7	1.4	0.5	139	15.3	32.3	0.47	42.6	1.12	5.4	0.5	3.9
2	32/F	48	12.7	3.2	1.1	1.7	0.2	196	16.0	32.3	0.49	29.7	1.63	15.0	1.5	5.5
3	53/F	86	13.2	2.5	0.2	1.6	0.3	200	25.7	21.7	1.18	39.1	1.21	11.7	1.2	0.6
4	48/M	120	15.9	3.4	1.1	1.7	0.7	205	20.3	30.1	0.67	30.9	1.63	13.3	1.8	3.6
5	73/M	96	13.4	3.0	1.6	1.0	0.6	135	21.6	29.4	0.73	36.5	1.40	8.7	3.0	0.8
6	61/F	65	12.4	3.0	1.1	1.6	0.3	241	20.5	33.6	0.61	30.3	1.78	12.0	1.4	2.3
7	65/F	131	13.1	4.5	1.7	2.2	0.5	273	14.3	31.5	0.45	34.2	1.34	12.9	4.0	4.0
8	71/F	24	13.3	4.1	1.5	2.3	0.3	147	20.1	29.7	0.68	38.3	1.30	8.8	1.1	2.0
9	65/F	50	12.4	4.1	1.8	2.0	0.3	126	15.5	28.1	0.55	29.0	1.50	21.1	3.4	2.9
10	32/F	27	12.1	3.6	1.2	1.8	0.5	259	20.0	30.4	0.66	29.0	1.74	16.1	1.6	3.0
11	60/F	144	13.8	4.5	1.7	2.5	0.3	220	20.0	30.1	0.66	28.6	1.75	15.6	3.0	2.7
12	74/F	18	11.5	3.1	1.6	1.2	0.2	156	18.5	33.7	0.55	29.8	1.75	12.8	3.5	1.7
13	48/F	120	13.2	3.5	1.6	1.4	0.4	243	21.4	30.5	0.70	26.4	1.96	19.0	1.0	1.7
14	68/F	112	13.4	5.8	1.8	3.1	0.4	231	17.6	21.9	0.80	45.9	0.86	9.0	3.0	2.6
15	70/F	16	13.9	3.2	1.3	1.5	0.3	169	16.2	31.1	0.52	34.6	1.37	13.6	0.8	3.7
16	65/F	103	13.9	3.6	1.7	1.6	0.3	244	21.3	31.2	0.68	29.7	1.77	10.4	4.7	2.7
17	52/F	100	13.1	4.1	1.5	2.1	0.4	229	18.7	31.2	0.60	32.7	1.53	11.8	1.7	3.9
18	66/F	43	13.7	4.2	1.7	1.7	0.4	211	18.7	32.4	0.58	33.8	1.51	10.2	1.7	3.2
19	60/F	83	13.0	3.0	1.4	1.2	0.3	210	18.1	26.4	0.69	40.6	1.10	9.4	2.5	3.0
20	32/F	72	12.8	3.3	1.5	1.4	0.3	257	17.8	34.6	0.51	30.5	1.65	13.5	1.9	3.7
21	50/F	125	13.3	3.2	1.1	1.7	0.2	196	22.3	28.4	0.78	35.2	1.44	9.0	1.3	3.8
22	50/F	97	11.7	3.1	1.4	1.4	0.3	121	23.8	26.7	0.89	36.8	1.37	6.7	2.8	3.2
23	63/F	180	11.5	2.4	1.5	0.7	0.2	166	23.4	29.3	0.80	37.7	1.40	7.9	0.6	1.0
24	55/F	51	13.3	3.5	1.6	1.5	0.4	278	20.1	31.4	0.64	32.1	1.60	11.9	2.2	2.3
25	63/F	125	12.9	4.1	1.5	2.0	0.5	228	20.8	30.3	0.69	31.1	1.64	11.7	2.9	3.2
26	35/F	60	12.9	3.1	1.2	1.5	0.3	224	18.4	34.6	0.53	30.1	1.76	12.1	2.0	2.8
27	44/F	12	13.0	4.9	1.4	2.6	0.3	189	15.5	32.8	0.47	31.7	1.52	14.0	1.5	4.5
28	70/F	120	12.1	3.6	1.2	1.8	0.5	259	14.3	31.5	0.45	34.2	1.34	12.9	4.0	4.0
29	77/F	121	13.4	3.7	1.7	1.6	0.3	100	21.3	31.2	0.68	29.7	1.77	10.4	4.7	2.7
30	56/F	130	13.6	3.0	1.4	1.2	0.3	253	21.3	31.2	0.68	28.7	1.83	11.4	4.7	2.7
31	73/F	120	12.7	5.3	1.7	2.7	0.7	182	17.0	31.3	0.54	30.7	1.57	14.0	1.5	5.5
32	33/F	72	13.8	3.5	1.2	1.9	0.3	188	17.0	33.3	0.51	30.7	1.64	15.0	1.5	2.5

Hgb indicates hemoglobin; WBC, white blood cells; Neutro, neutrophils; Lympho, lymphocytes; Mono, monocytes; Plts, platelets; PGP, proliferating granulocyte pool; MGP, maturating granulocyte pool; M/E ratio, myeloid-erythroid series ratio; Plasma, plasmacytes.

Data at the time of study. BM differential was determined by evaluating at least 2000 consecutive nucleated cells in BM smears stained with May-Grünwald-Giemsa.

†

Total sum of the percentages of blast cells plus promyelocytes plus myelocytes within the BM nucleated cells.

‡

Total sum of the percentages of metamyelocytes plus band cells plus mature neutrophils within the BM nucleated cells.

F1-153

The mean PGP/MGP in the patients was 0.6 ± 0.15 versus 0.28 ± 0.05 in the controls (P < .0001) suggesting a shift to the left of the myeloid series.

F1-155

The mean M/E ratio in the patients was 1.52 ± 0.24 versus 2.21 ± 0.37 in the controls (P < .0001) suggesting a myeloid cell hypoplasia.

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