Table 1.

Mean ± SD of PBT relative to start of plasmin or TPA infusion

PlasminTPA
4 mg/kg6 mg/kg8 mg/kg0.25 mg/kg0.5 mg/kg1 mg/kg
Before treatment 2.1 ± 0.6 2.2 ± 0.4 2.6 ± 1.4 1.8 ± 0.7 2.4 ± 0.9 2.3 ± 0.9 
Treatment 2.3 ± 1.9 3.0 ± 1.0 5.6 ± 8.0 2.1 ± 1.3 3.2 ± 1.2 8.2 ± 20.0 
After treatment 2.6 ± 1.4 3.6 ± 2.8* 25.5 ± 41.0 1.9 ± 1.1 3.0 ± 1.2 2.6 ± 1.2 
PlasminTPA
4 mg/kg6 mg/kg8 mg/kg0.25 mg/kg0.5 mg/kg1 mg/kg
Before treatment 2.1 ± 0.6 2.2 ± 0.4 2.6 ± 1.4 1.8 ± 0.7 2.4 ± 0.9 2.3 ± 0.9 
Treatment 2.3 ± 1.9 3.0 ± 1.0 5.6 ± 8.0 2.1 ± 1.3 3.2 ± 1.2 8.2 ± 20.0 
After treatment 2.6 ± 1.4 3.6 ± 2.8* 25.5 ± 41.0 1.9 ± 1.1 3.0 ± 1.2 2.6 ± 1.2 

Pretreatment times were −30, −10, and 0 minutes; treatment times, 10 and 30 minutes; and posttreatment times, 60, 70, 90, 120, and 180 minutes.

*

P = .02 versus before treatment.

P = .027 and .04 versus before treatment and after treatment.

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