Frequency of upper-limb and lower-extremity DVTs in HIT patients and controls with and without CVCs
| . | Upper-extremity DVT . | Lower-extremity DVT . |
|---|---|---|
| HIT patients vs non-HIT controls (no. 1 after orthopedic surgery; no. 2 intensive-care unit patients) | ||
| HIT | 14/260 (5.4%, 3.0-8.9) | 110/260 (42.3%, 36.2-48.6) |
| vs controls no. 1 | 0/637 (0%, 0.0-0.6) | 26/637 (4.1%, 2.7-5.9) |
| P | <.0001 | <.0001 |
| vs controls no. 2 | 3/261 (1.1%, 0.2-3.3) | 25/261 (9.6%, 6.3-13.8) |
| P | .0066 | <.0001 |
| HIT patients | ||
| +CVC vs | 14/145 (9.7%, 5.4-15.7) | 49/145 (33.8%, 26.2-42.1) |
| −CVC | 0/115 (0%, 0.0-3.2) | 61/115 (53.0%, 43.5-62.4) |
| P | .00035 | .0024 |
| Non-HIT control no. 1 (after orthopedic surgery) | ||
| +CVC vs | 0/263 (0%, 0.0-1.4) | 10/263 (3.8%, 1.8-6.9) |
| −CVC | 0/374 (0%, 0.0-1.0) | 16/374 (4.3%, 2.5-6.9) |
| P | NA | .84 |
| Non-HIT control no. 2 (intensive-care unit patients) | ||
| +CVC | 3*/221 (1.4%, 0.3-3.9) | 24/221 (10.9%, 7.1-15.7) |
| −CVC | 0/40 (0%, 0.0-8.8) | 1/40 (2.5%, 0.1-13.2) |
| P | 1.00 | .14 |
| . | Upper-extremity DVT . | Lower-extremity DVT . |
|---|---|---|
| HIT patients vs non-HIT controls (no. 1 after orthopedic surgery; no. 2 intensive-care unit patients) | ||
| HIT | 14/260 (5.4%, 3.0-8.9) | 110/260 (42.3%, 36.2-48.6) |
| vs controls no. 1 | 0/637 (0%, 0.0-0.6) | 26/637 (4.1%, 2.7-5.9) |
| P | <.0001 | <.0001 |
| vs controls no. 2 | 3/261 (1.1%, 0.2-3.3) | 25/261 (9.6%, 6.3-13.8) |
| P | .0066 | <.0001 |
| HIT patients | ||
| +CVC vs | 14/145 (9.7%, 5.4-15.7) | 49/145 (33.8%, 26.2-42.1) |
| −CVC | 0/115 (0%, 0.0-3.2) | 61/115 (53.0%, 43.5-62.4) |
| P | .00035 | .0024 |
| Non-HIT control no. 1 (after orthopedic surgery) | ||
| +CVC vs | 0/263 (0%, 0.0-1.4) | 10/263 (3.8%, 1.8-6.9) |
| −CVC | 0/374 (0%, 0.0-1.0) | 16/374 (4.3%, 2.5-6.9) |
| P | NA | .84 |
| Non-HIT control no. 2 (intensive-care unit patients) | ||
| +CVC | 3*/221 (1.4%, 0.3-3.9) | 24/221 (10.9%, 7.1-15.7) |
| −CVC | 0/40 (0%, 0.0-8.8) | 1/40 (2.5%, 0.1-13.2) |
| P | 1.00 | .14 |
All data are DVT events/group (% frequency, 95% CI); theP values are based upon χ2, Fisher exact test (2-sided).
+CVC indicates presence of a central venous catheter; −CVC, absence of a central venous catheter; DVT, proximal deep-vein thrombosis; HIT, heparin-induced thrombocytopenia; and NA, not applicable.
All 3 upper-limb DVTs in the control group occurred at the site of a CVC.