Comparison of clinical characteristics of patients in the present series and 2 previous series3-150
| Characteristic . | Present study, % N = 99 . | Soubrier et al,22 % N = 25 . | Nakanishi et al,8% N = 102 . |
|---|---|---|---|
| Polyneuropathy | |||
| Peripheral neuropathy | 100 | 100 | 100 |
| Cerebrospinal fluid protein more than 50 mg/dL | 1003-152 | 1003-152 | 973-152 |
| Organomegaly | 50 | NR | NR |
| Hepatomegaly | 24 | 68 | 78 |
| Splenomegaly | 22 | 52 | 35 |
| Lymphadenopathy | 26 | 52 | 61 |
| Castleman disease | 11 | 24 | 19 |
| Endocrinopathy | 67 | NR | NR |
| Gonadal axis abnormality | 55 | NR | NR |
| Adrenal axis abnormality | 16 | NR | NR |
| Increased prolactin value | 5 | NR | NR |
| Gynecomastia or galactorrhea | 18 | NR | NR |
| Diabetes mellitus | 3 | 36 | 25 |
| Hypothyroidism | 14 | 36 | NR |
| Hyperparathyroidism | 3 | NR | NR |
| Monoclonal plasma cell dyscrasia | 100 | 100 | 75 |
| M component on serum protein electrophoresis | 54 | 100 | 70 |
| Skin changes | 68 | NR | NR |
| Hyperpigmentation | 46 | 48 | 93 |
| Acrocyanosis and plethora | 19 | NR | NR |
| Hemangioma/telangiectasia | 9 | 32 | NR |
| Hypertrichosis | 26 | 24 | 74 |
| Thickening | 5 | 28 | 61 |
| Papilledema | 29 | 40 | 55 |
| Extravascular volume overload | 29 | NR | NR |
| Peripheral edema | 24 | 80 | 89 |
| Ascites | 7 | 32 | 52 |
| Pleural effusion | 3 | 24 | 35 |
| Bone lesions | 97 | 68 | 54 |
| Osteosclerotic only3-151 | 47 | 41 | 56 |
| Mixed sclerotic and lytic3-151 | 51 | 59 | 31 |
| Lytic only3-151 | 2 | 0 | 13 |
| Solitary lesion3-151 | 45 | 41 | 45 |
| 2 or 3 lesions3-151 | 23 | NR | NR |
| More than 1 lesion3-151 | 54 | 59 | 45 |
| More than 3 lesions3-151 | 32 | NR | NR |
| Other features | |||
| Weight loss more than 10 pounds | 37 | NR | NR |
| Fatigue | 31 | NR | NR |
| Thrombocytosis: platelet count more than 450 × 103/μL | 54 | 88 | NR |
| Polycythemia: hemoglobin more than 15 g/dL in women and more than 17 g/dL in men | 18 | 12 | 19 |
| Clubbing | 5 | 32 | 49 |
| Characteristic . | Present study, % N = 99 . | Soubrier et al,22 % N = 25 . | Nakanishi et al,8% N = 102 . |
|---|---|---|---|
| Polyneuropathy | |||
| Peripheral neuropathy | 100 | 100 | 100 |
| Cerebrospinal fluid protein more than 50 mg/dL | 1003-152 | 1003-152 | 973-152 |
| Organomegaly | 50 | NR | NR |
| Hepatomegaly | 24 | 68 | 78 |
| Splenomegaly | 22 | 52 | 35 |
| Lymphadenopathy | 26 | 52 | 61 |
| Castleman disease | 11 | 24 | 19 |
| Endocrinopathy | 67 | NR | NR |
| Gonadal axis abnormality | 55 | NR | NR |
| Adrenal axis abnormality | 16 | NR | NR |
| Increased prolactin value | 5 | NR | NR |
| Gynecomastia or galactorrhea | 18 | NR | NR |
| Diabetes mellitus | 3 | 36 | 25 |
| Hypothyroidism | 14 | 36 | NR |
| Hyperparathyroidism | 3 | NR | NR |
| Monoclonal plasma cell dyscrasia | 100 | 100 | 75 |
| M component on serum protein electrophoresis | 54 | 100 | 70 |
| Skin changes | 68 | NR | NR |
| Hyperpigmentation | 46 | 48 | 93 |
| Acrocyanosis and plethora | 19 | NR | NR |
| Hemangioma/telangiectasia | 9 | 32 | NR |
| Hypertrichosis | 26 | 24 | 74 |
| Thickening | 5 | 28 | 61 |
| Papilledema | 29 | 40 | 55 |
| Extravascular volume overload | 29 | NR | NR |
| Peripheral edema | 24 | 80 | 89 |
| Ascites | 7 | 32 | 52 |
| Pleural effusion | 3 | 24 | 35 |
| Bone lesions | 97 | 68 | 54 |
| Osteosclerotic only3-151 | 47 | 41 | 56 |
| Mixed sclerotic and lytic3-151 | 51 | 59 | 31 |
| Lytic only3-151 | 2 | 0 | 13 |
| Solitary lesion3-151 | 45 | 41 | 45 |
| 2 or 3 lesions3-151 | 23 | NR | NR |
| More than 1 lesion3-151 | 54 | 59 | 45 |
| More than 3 lesions3-151 | 32 | NR | NR |
| Other features | |||
| Weight loss more than 10 pounds | 37 | NR | NR |
| Fatigue | 31 | NR | NR |
| Thrombocytosis: platelet count more than 450 × 103/μL | 54 | 88 | NR |
| Polycythemia: hemoglobin more than 15 g/dL in women and more than 17 g/dL in men | 18 | 12 | 19 |
| Clubbing | 5 | 32 | 49 |
NR indicates not reported.
The percentage of patients with the given characteristic is shown. Percentages are based on the total number of patients in the series, with the exception of cerebrospinal fluid protein, which includes the actual number tested.
Percentage of patients with bone lesions.
Only 28, 23, and 73 patients, respectively, were tested; percentage represents percent positive of those tested.