Alignment of VWF A1 domain amino acids
| Mouse (1) DTP EPPLHNFYCS KLLDLVFLLD GSSMLSEAEF-530 |
| Human (2) DIS EPPLHDFYCS RLLDLVFLLD GSSRLSEAEF |
| Dog (3) DTP EPPLHDFHCS RLLDLVFLLD GSSKLSEDEF |
| Pig (4) DTP EPPLHDFFCS KLLDLVFLLD GSDKLSEADF |
| Rabbit (5) DTP EPPLHDFYWS NLMDLVFLLD GSAQLSEAEF |
| (1) EVLKAFVVGM MERLHISQKR TRVAVVEYHD GSRAYLELKA-570 |
| (2) EVLKAFVVDM MERLRISQKW VRVAVVEYHD GSHAYIGLKD |
| (3) EVLKVFVVGM MEHLHISQKR IRVAVVEYHD GSHAVIELKD |
| (4) EALKVFVVGM MEHLHISQKH IRVAVVEYHD GPHAVISLQD |
| (5) GVLKAFVVSV MERLHISQKR IRVAVVEYHD GSHSYISLKD |
| (1) RKRPSELRRI TSQIKYTGSQ VASTSEVLKY TLFQIFGKID-610 |
| (2) RKRPSELRRI ASQVKYAGSQ VASTSEVLKY TLFQIFSKID |
| (3) RKRPSELRRI TSQVKYAGSE VASTSEVLKY TLFQIFGKID |
| (4) RKRPSELRRI ASQVKYAGSE VASISEVLKY TLFQIFGRVD |
| (5) RKRPSELRRI ASQVKYAGGP VASTSEVLKY TLFHIFSNVD |
| (1) RPEASHITLL LTASQEPPRM ARNLVRYVQG LKKKKVIVIP-650 |
| (2) RPEASRIALL LMASQEPQRM SRNFVRYVQG LKKKKVIVIP |
| (3) RPEASRIALL LMASQEPSRL ARNLVRYVQG LKKKKVIVIP |
| (4) RPEASRIALL LMASQEPRRL AQNLARYLQG LKKKKVIVIP |
| (5) RPEASRIALL LSASQETPRM VRNLVRYAQG LKKEKVIVIP |
| (1) VGIGPHASLK QIRLIEKQAP ENKAFLLSGV DELEQRRDEI-690 |
| (2) VGIGPHANLK QIRLIEKQAP ENKAFVLSSV DELEQQRDEI |
| (3) VGIGPHASLK QIHLIEKQAP ENKAFVFSGV DELEQRRDEI |
| (4) VGIGPHVSLK QIRLIEKQAP ENKAFVVSGV DELEQRKNEI |
| (5) VGIGPHVSLR QIHLIEKQAP ENKAFVLSGV DELEQRRDEI |
| (1) VSYLCDLAPE APAP T QPPOV AHV T VSPGIA GI S-723 |
| (2) VSYLCDLAPE APPP T LPPHN AQV T VGPGLL GV S |
| (3) INYLCDLAPE APAP T QHPPM AQV T VGSELL GV S |
| (4) ISYLCDLAPE VPAP T RRPLV AQV T VAPELP GV S |
| (5) ISYLCDLGPE APVP T QRPPT ARV T VSPGQL GV S |
| Mouse (1) DTP EPPLHNFYCS KLLDLVFLLD GSSMLSEAEF-530 |
| Human (2) DIS EPPLHDFYCS RLLDLVFLLD GSSRLSEAEF |
| Dog (3) DTP EPPLHDFHCS RLLDLVFLLD GSSKLSEDEF |
| Pig (4) DTP EPPLHDFFCS KLLDLVFLLD GSDKLSEADF |
| Rabbit (5) DTP EPPLHDFYWS NLMDLVFLLD GSAQLSEAEF |
| (1) EVLKAFVVGM MERLHISQKR TRVAVVEYHD GSRAYLELKA-570 |
| (2) EVLKAFVVDM MERLRISQKW VRVAVVEYHD GSHAYIGLKD |
| (3) EVLKVFVVGM MEHLHISQKR IRVAVVEYHD GSHAVIELKD |
| (4) EALKVFVVGM MEHLHISQKH IRVAVVEYHD GPHAVISLQD |
| (5) GVLKAFVVSV MERLHISQKR IRVAVVEYHD GSHSYISLKD |
| (1) RKRPSELRRI TSQIKYTGSQ VASTSEVLKY TLFQIFGKID-610 |
| (2) RKRPSELRRI ASQVKYAGSQ VASTSEVLKY TLFQIFSKID |
| (3) RKRPSELRRI TSQVKYAGSE VASTSEVLKY TLFQIFGKID |
| (4) RKRPSELRRI ASQVKYAGSE VASISEVLKY TLFQIFGRVD |
| (5) RKRPSELRRI ASQVKYAGGP VASTSEVLKY TLFHIFSNVD |
| (1) RPEASHITLL LTASQEPPRM ARNLVRYVQG LKKKKVIVIP-650 |
| (2) RPEASRIALL LMASQEPQRM SRNFVRYVQG LKKKKVIVIP |
| (3) RPEASRIALL LMASQEPSRL ARNLVRYVQG LKKKKVIVIP |
| (4) RPEASRIALL LMASQEPRRL AQNLARYLQG LKKKKVIVIP |
| (5) RPEASRIALL LSASQETPRM VRNLVRYAQG LKKEKVIVIP |
| (1) VGIGPHASLK QIRLIEKQAP ENKAFLLSGV DELEQRRDEI-690 |
| (2) VGIGPHANLK QIRLIEKQAP ENKAFVLSSV DELEQQRDEI |
| (3) VGIGPHASLK QIHLIEKQAP ENKAFVFSGV DELEQRRDEI |
| (4) VGIGPHVSLK QIRLIEKQAP ENKAFVVSGV DELEQRKNEI |
| (5) VGIGPHVSLR QIHLIEKQAP ENKAFVLSGV DELEQRRDEI |
| (1) VSYLCDLAPE APAP T QPPOV AHV T VSPGIA GI S-723 |
| (2) VSYLCDLAPE APPP T LPPHN AQV T VGPGLL GV S |
| (3) INYLCDLAPE APAP T QHPPM AQV T VGSELL GV S |
| (4) ISYLCDLAPE VPAP T RRPLV AQV T VAPELP GV S |
| (5) ISYLCDLGPE APVP T QRPPT ARV T VSPGQL GV S |
Residues, numbered according to the sequence of the mature human VWF, are aligned for murine, human, canine, porcine, and rabbit VWF A1 domain (residues 498-723). The critical disulfide bridge residues delineating the AI domain (Cys509 and Cys695) are underlined. The 9 residues at positions 563, 566, 570, 581, 584, 587, 616, 618, and 622, indicated with boldfacing, show partial to complete homology between human, canine, porcine, and rabbit VWF AI domains and no homology with murine residues.