STAT3 isoforms
| . | Description . | Molecular weight (kDa) . |
|---|---|---|
| STAT3α | Full length | 92 |
| STAT3β | Missing c-terminal transactivation domain; functionally distinct, either dominant negative or altered binding | 83 |
| STAT3γ | Lacking tyrosine residue; can still be recruited to tyrosine-phosphorylated receptor proteins by the binding function of the remaining SH2 domain but signaling by the receptor complex terminates | 72 |
| STAT3δ | Unknown | 64 |
| . | Description . | Molecular weight (kDa) . |
|---|---|---|
| STAT3α | Full length | 92 |
| STAT3β | Missing c-terminal transactivation domain; functionally distinct, either dominant negative or altered binding | 83 |
| STAT3γ | Lacking tyrosine residue; can still be recruited to tyrosine-phosphorylated receptor proteins by the binding function of the remaining SH2 domain but signaling by the receptor complex terminates | 72 |
| STAT3δ | Unknown | 64 |