Table 3. STATs structure Domain . Role .... | American Society of Hematology

Table 3.

STATs structure

Domain	Role	Reference
Oligomerization domain	Interacts with other proteins and mediates oligomerization of STAT dimers to form tetramers.	40,41
DNA binding domain	Defines the DNA-binding specificity and mediates distinct signals for specific ligands.	42-44
SH2 domain	Mediates specific interactions between STAT-receptor, STAT-JAK, and STAT-STAT.	45-49
Carboxyl-terminal domain	Transcriptional activation domain that is thought to regulate the transcriptional activity of STATs and provide functional specificity.	50-53
Tyrosine residue	Phosphorylation site in the c-terminal domain approximately 700 residues from the N-terminus that regulates the DNA-binding activity of all STATs. On phosphorylation, mediates STAT dimerization by binding to the SH2 domain of the reciprocal STAT molecule.	10,12
Serine residue^3-150	A second phosphorylation site in the c-terminal domain.^3-151	54,55

Domain	Role	Reference
Oligomerization domain	Interacts with other proteins and mediates oligomerization of STAT dimers to form tetramers.	40,41
DNA binding domain	Defines the DNA-binding specificity and mediates distinct signals for specific ligands.	42-44
SH2 domain	Mediates specific interactions between STAT-receptor, STAT-JAK, and STAT-STAT.	45-49
Carboxyl-terminal domain	Transcriptional activation domain that is thought to regulate the transcriptional activity of STATs and provide functional specificity.	50-53
Tyrosine residue	Phosphorylation site in the c-terminal domain approximately 700 residues from the N-terminus that regulates the DNA-binding activity of all STATs. On phosphorylation, mediates STAT dimerization by binding to the SH2 domain of the reciprocal STAT molecule.	10,12
Serine residue^3-150	A second phosphorylation site in the c-terminal domain.^3-151	54,55

F3-150

All except STAT2 and STAT6.

F3-151

In STAT1 and STAT3, the phosphorylation of Ser-727 enhances DNA binding affinity56 and activation of transcription57 and is necessary for optimal biologic activity of STAT3 in cellular transformation induced by Src.58 59

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