Table 1. Summary of in vitro and in vivo... | American Society of Hematology

Table 1.

Summary of in vitro and in vivo studies that demonstrate stages in the pathogenesis of Mll-AF9 fusion gene leukemia

	In vitro			In vivo
Stage of pathogenesis	Expansion of myeloid progenitors	Progenitor replating beyond first generation	Ability to establish long-term cell lines	Transplanted cells resulting in early leukemia in animals
Prenatal	Yes	Limited	No	No
Early postnatal	Yes	Enhanced	No	No
Adult	Yes	Unlimited	Yes	Yes

	In vitro			In vivo
Stage of pathogenesis	Expansion of myeloid progenitors	Progenitor replating beyond first generation	Ability to establish long-term cell lines	Transplanted cells resulting in early leukemia in animals
Prenatal	Yes	Limited	No	No
Early postnatal	Yes	Enhanced	No	No
Adult	Yes	Unlimited	Yes	Yes