Table 2. Secondary repopulating ability... | American Society of Hematology

Table 2.

Secondary repopulating ability of CD34⁺ and IBMI-CD34⁻ SRCs

Type and no. of cells transplanted into PR^*	% Human cells in PR^†	Sorted cells transplanted into SR	Incidence of engraftment in SR	% Human cells in SR^‡
Lin⁻CD34^high, 5 × 10⁴	31.4-80.0 (72.1)^2-153	CD45⁺CD34⁺	11/15	0.1-11 (4.7)^2-153
		CD45⁺CD34⁻	0/15	0
Lin⁻CD34⁻, 5 × 10⁴	15.3-39.6 (23.4)^2-153	CD45⁺CD34⁺	4/5	0.1-0.9 (0.15)^2-153
		CD45⁺CD34⁻	0/5	0

Type and no. of cells transplanted into PR^*	% Human cells in PR^†	Sorted cells transplanted into SR	Incidence of engraftment in SR	% Human cells in SR^‡
Lin⁻CD34^high, 5 × 10⁴	31.4-80.0 (72.1)^2-153	CD45⁺CD34⁺	11/15	0.1-11 (4.7)^2-153
		CD45⁺CD34⁻	0/15	0
Lin⁻CD34⁻, 5 × 10⁴	15.3-39.6 (23.4)^2-153	CD45⁺CD34⁺	4/5	0.1-0.9 (0.15)^2-153
		CD45⁺CD34⁻	0/5	0

5 × 10⁴ Lin⁻CD34^highcells were estimated to contain 40 to 50 SRCs. In contrast, 5 × 10⁴ Lin⁻CD34⁻ cells contained only 2 or 3 SRCs.

†

Human cell repopulation of BMs in primary recipients (PR) was serially analyzed 8 to 16 weeks after transplantation with Lin⁻CD34^high cells and 12 to 16 weeks after transplantation with Lin⁻CD34⁻ cells.

‡

Human cell repopulation of BMs in secondary recipients (SR) was analyzed 12 weeks after secondary transplantation.

F2-153

Median values are presented in parentheses.

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