Table 5. Correlations between responses... | American Society of Hematology

Table 5.

Correlations between responses to THAL-PRED and patient characteristics

	Hemoglobin response, P	Platelet response, P	Spleen response, P
Demographic characteristics
Age	.77	.04^5-150	.85
Sex	.89	.08	.18
MMM subtype	.67	.58	.71
Duration of disease	.79	.72	.69
Dupriez MMM score³⁵	.15	.22	.58
Spleen size	.32	< .01^5-150	.75
Laboratory values
Hemoglobin	.74	.18	.71
Erythrocyte Tx Dep	.81	.12	.03^5-150
Leukocyte count	.12	.25	.89
Platelet count	.69	< .01^5-150	.76
CD34⁺ cell count	.03^5-150	.57	.39
Blast, %	.03^5-150	.48	.33
LDH	.12	.23	.72
Bone marrow results
Marrow cellularity	.84	< .01^5-150	.39
RF grade	.63	.60	.55
OS grade	.23	.43	.24
Marked AG, grade 4	.03^5-150	.12	.22
Abnormal karyotype	.39	.11	.63
Ancillary assays
Spleen grade,^99mTc-SC	.15	.03^5-150	.19
Lung EMH,^99mTc-SC	.62	.82	.02^5-150
Bone marrow,^99mTc-SC uptake	.26	.36	.03^5-150
Urinary VEGF	.45	.31	.10
Urinary bFGF	.72	.50	.81
Urinary TSP	.90	.03^5-150	.23

	Hemoglobin response, P	Platelet response, P	Spleen response, P
Demographic characteristics
Age	.77	.04^5-150	.85
Sex	.89	.08	.18
MMM subtype	.67	.58	.71
Duration of disease	.79	.72	.69
Dupriez MMM score³⁵	.15	.22	.58
Spleen size	.32	< .01^5-150	.75
Laboratory values
Hemoglobin	.74	.18	.71
Erythrocyte Tx Dep	.81	.12	.03^5-150
Leukocyte count	.12	.25	.89
Platelet count	.69	< .01^5-150	.76
CD34⁺ cell count	.03^5-150	.57	.39
Blast, %	.03^5-150	.48	.33
LDH	.12	.23	.72
Bone marrow results
Marrow cellularity	.84	< .01^5-150	.39
RF grade	.63	.60	.55
OS grade	.23	.43	.24
Marked AG, grade 4	.03^5-150	.12	.22
Abnormal karyotype	.39	.11	.63
Ancillary assays
Spleen grade,^99mTc-SC	.15	.03^5-150	.19
Lung EMH,^99mTc-SC	.62	.82	.02^5-150
Bone marrow,^99mTc-SC uptake	.26	.36	.03^5-150
Urinary VEGF	.45	.31	.10
Urinary bFGF	.72	.50	.81
Urinary TSP	.90	.03^5-150	.23

P corrected for effects of multiple comparisons. Reticulin fibrosis and osteosclerosis were graded 0 to 4; angiogenesis was graded 1 to 4.

Statistically significant.