Characteristics of 21 patients with MMM treated with THAL-PRED
| Patient characteristic . | . |
|---|---|
| Type of MMM, no. (%) | |
| AMM | 15 (72) |
| PPMM | 3 (14) |
| PTMM | 3 (14) |
| Sex, no. (%) | |
| Male | 16 (76) |
| Female | 5 (24) |
| Age, y, mean (range) | |
| At diagnosis | 61 (38-73) |
| At time of trial | 63 (46-74) |
| Dupriez MMM prognostic score,35 no. (%) | |
| 0 | 5 (24) |
| 1 | 10 (48) |
| 2 | 6 (28) |
| MMM-related symptoms, no. (%) | |
| Weight loss (> 20% baseline) | 5 (24) |
| Fevers | 3 (14) |
| Night sweats | 6 (29) |
| Bone pain | 3 (14) |
| Laboratory studies/physical exam at enrollment, mean (range) | |
| Hemoglobin level, g/dL | 9 (7.2-12.9) |
| Leukocyte count, × 109/L | 7.7 (1.4-25.6) |
| Absolute neutrophil count, × 109/L | 3.6 (0.7-14.8) |
| Immature myeloid (nonblasts) | 7% (0%-21%) |
| Myeloblasts | 1% (0%-19%) |
| Nucleated erythrocytes/100 leukocytes | 1.0% (0%-23%) |
| Peripheral blood CD34+ count/μL, n = 6 | 84 (3-1890) |
| Platelet count, × 109/L | 157 (23-448) |
| Lactate dehydrogenase, U/L; 112-257 normal range | 515 (170-766) |
| Alkaline phosphatase, U/L; 98-251 normal range | 232 (117-802) |
| Aspartate transaminase, U/L | 26 (9-107) |
| Creatinine, mg/dL | 1.1 (0.8-2.0) |
| Spleen size, cm below left costal margin | 14 (0-26) |
| Patient characteristic . | . |
|---|---|
| Type of MMM, no. (%) | |
| AMM | 15 (72) |
| PPMM | 3 (14) |
| PTMM | 3 (14) |
| Sex, no. (%) | |
| Male | 16 (76) |
| Female | 5 (24) |
| Age, y, mean (range) | |
| At diagnosis | 61 (38-73) |
| At time of trial | 63 (46-74) |
| Dupriez MMM prognostic score,35 no. (%) | |
| 0 | 5 (24) |
| 1 | 10 (48) |
| 2 | 6 (28) |
| MMM-related symptoms, no. (%) | |
| Weight loss (> 20% baseline) | 5 (24) |
| Fevers | 3 (14) |
| Night sweats | 6 (29) |
| Bone pain | 3 (14) |
| Laboratory studies/physical exam at enrollment, mean (range) | |
| Hemoglobin level, g/dL | 9 (7.2-12.9) |
| Leukocyte count, × 109/L | 7.7 (1.4-25.6) |
| Absolute neutrophil count, × 109/L | 3.6 (0.7-14.8) |
| Immature myeloid (nonblasts) | 7% (0%-21%) |
| Myeloblasts | 1% (0%-19%) |
| Nucleated erythrocytes/100 leukocytes | 1.0% (0%-23%) |
| Peripheral blood CD34+ count/μL, n = 6 | 84 (3-1890) |
| Platelet count, × 109/L | 157 (23-448) |
| Lactate dehydrogenase, U/L; 112-257 normal range | 515 (170-766) |
| Alkaline phosphatase, U/L; 98-251 normal range | 232 (117-802) |
| Aspartate transaminase, U/L | 26 (9-107) |
| Creatinine, mg/dL | 1.1 (0.8-2.0) |
| Spleen size, cm below left costal margin | 14 (0-26) |