Table 1. Effects of in vivo oral... | American Society of Hematology

Table 1.

Effects of in vivo oral treatment with ICA-17043 (10 mg/kg twice a day) on SAD mice

	ICA-17043 (n = 6)
Gardos channel Rb⁺ flux, mmol/L cell × min
Baseline	11.71 ± 1.21
11 d	3.03 ± 1.32^*
21 d	1.52 ± 0.45^*
Erythrocyte K content, mmol/kg Hb
Baseline	392 ± 19.9
11 d	483 ± 13.5^*
21 d	479 ± 40.0^*
Erythrocyte Na content, mmol/kg Hb
Baseline	47.4 ± 3.7
11 d	47.4 ± 8.6
21 d	54.8 ± 6.7
Erythrocyte density (D₅₀)
Baseline	1.100 ± 0.002
11 d	1.089 ± 0.001^†
21 d	1.088 ± 0.001^†

	ICA-17043 (n = 6)
Gardos channel Rb⁺ flux, mmol/L cell × min
Baseline	11.71 ± 1.21
11 d	3.03 ± 1.32^*
21 d	1.52 ± 0.45^*
Erythrocyte K content, mmol/kg Hb
Baseline	392 ± 19.9
11 d	483 ± 13.5^*
21 d	479 ± 40.0^*
Erythrocyte Na content, mmol/kg Hb
Baseline	47.4 ± 3.7
11 d	47.4 ± 8.6
21 d	54.8 ± 6.7
Erythrocyte density (D₅₀)
Baseline	1.100 ± 0.002
11 d	1.089 ± 0.001^†
21 d	1.088 ± 0.001^†

Data are presented as means ± SDs.

P < .005 compared with baseline.

P < .05 compared with baseline.