Exposure to cyclophosphamide and its metabolites CEPM and HCY in relation to relapse of hematologic malignancy after transplantation
| AUCs . | Chronic myeloid leukemia in chronic phase . | Other hematologic malignancies . | ||
|---|---|---|---|---|
| Relapse, n = 7 . | No relapse, n = 66 . | Relapse, n = 22 . | No relapse, n = 52 . | |
| AUCCEPM | 381 (303-547) | 388 (117-664) | 366 (118-706) | 418 (123-1881) |
| AUCHCY | 153 (72-269) | 142 (62-284) | 161 (61-283) | 127 (38-298) |
| AUCCY | 5698 (4516-7099) | 6507 (3588-8864) | 6356 (4497-7968) | 5982 (2676-8761) |
| AUCs . | Chronic myeloid leukemia in chronic phase . | Other hematologic malignancies . | ||
|---|---|---|---|---|
| Relapse, n = 7 . | No relapse, n = 66 . | Relapse, n = 22 . | No relapse, n = 52 . | |
| AUCCEPM | 381 (303-547) | 388 (117-664) | 366 (118-706) | 418 (123-1881) |
| AUCHCY | 153 (72-269) | 142 (62-284) | 161 (61-283) | 127 (38-298) |
| AUCCY | 5698 (4516-7099) | 6507 (3588-8864) | 6356 (4497-7968) | 5982 (2676-8761) |
Numbers represent medians (ranges) of areas under the curve, expressed as μM·h.