AUCs for cyclophosphamide and its metabolites, expressed as μM·h
| AUCs . | All patients, SD (range) . | No SOS, n = 76 . | Mild SOS, n = 33 . | Moderate and severe SOS, n = 23 . | Moderate and severe SOS vs no SOS,P . | Mild SOS vs no SOS, P . |
|---|---|---|---|---|---|---|
| AUCDCCY | 598 ± 271 (210-1685) | 572 ± 278 | 672 ± 292 | 578 ± 202 | .4240 | .0373 |
| AUCHPPM | 104 ± 189 (14-1415) | 124 ± 245 | 73 ± 32 | 82 ± 33 | .1186 | .7871 |
| AUCCY | 6096 ± 1266 (2676-8864) | 5921 ± 1246 | 6032 ± 1175 | 6761 ± 1291 | .0041 | .6497 |
| AUCKetoCY | 238 ± 96 (85-648) | 233 ± 93 | 252 ± 113 | 235 ± 84 | .5480 | .4654 |
| AUCCEPM | 422 ± 193 (117-1881) | 369 ± 126 | 440 ± 124 | 569 ± 332 | .0002 | .0108 |
| AUCHCY | 158 ± 62 (38-298) | 165 ± 66 | 155 ± 57 | 139 ± 54 | .1164 | .4862 |
| AUCs . | All patients, SD (range) . | No SOS, n = 76 . | Mild SOS, n = 33 . | Moderate and severe SOS, n = 23 . | Moderate and severe SOS vs no SOS,P . | Mild SOS vs no SOS, P . |
|---|---|---|---|---|---|---|
| AUCDCCY | 598 ± 271 (210-1685) | 572 ± 278 | 672 ± 292 | 578 ± 202 | .4240 | .0373 |
| AUCHPPM | 104 ± 189 (14-1415) | 124 ± 245 | 73 ± 32 | 82 ± 33 | .1186 | .7871 |
| AUCCY | 6096 ± 1266 (2676-8864) | 5921 ± 1246 | 6032 ± 1175 | 6761 ± 1291 | .0041 | .6497 |
| AUCKetoCY | 238 ± 96 (85-648) | 233 ± 93 | 252 ± 113 | 235 ± 84 | .5480 | .4654 |
| AUCCEPM | 422 ± 193 (117-1881) | 369 ± 126 | 440 ± 124 | 569 ± 332 | .0002 | .0108 |
| AUCHCY | 158 ± 62 (38-298) | 165 ± 66 | 155 ± 57 | 139 ± 54 | .1164 | .4862 |
Based on the development of liver toxicity, that is, SOS. Data are expressed as the mean ± SD.