Genome-wide genetic linkage analysis of affected (CBA/H × C57BL/6)F1 × CBA/H backcross mice
| Chromosome . | Chromosome length, cM* . | No. of markers† . | Mean interval, cM ± SD‡ . | Maximum χ2 (P < .05)1-153 . | r-AML aberration incidence, %1-155 . | ||
|---|---|---|---|---|---|---|---|
| Marker . | Trisomy . | Monosomy . | |||||
| 1 | 127 | 17 | 7.1 ± 5.7 | 11.1 (.00086) | 4.0 | 6.0 | 0 |
| 2 | 114 | 10 | 10.4 ± 6.8 | 3.89 (.49) | 95 | NA | NA |
| 3 | 95 | 6 | 13.6 ± 3.4 | 0.54 | 14.9 | 0 | 2.3 |
| 4 | 84 | 10 | 7.6 ± 5.4 | 5.42 (.02) | 10.8 | 1.3 | 0 |
| 5 | 92 | 6 | 13.1 ± 2.6 | 3.36 | 8.5 | 4.0 | 0 |
| 6 | 75 | 11 | 6.3 ± 4.9 | 11.1 (.00086) | 17 | 15.0 | 1.5 |
| 7 | 74 | 5 | 12.2 ± 7.4 | 1.06 | 8.5 | 0 | 0 |
| 8 | 82 | 5 | 11.0 ± 6.0 | 1.03 | 4 | 0 | 0 |
| 9 | 74 | 5 | 12.3 ± 5.2 | 0.96 | 17 | 2.0 | 0 |
| 10 | 77 | 7 | 9.6 ± 4.4 | 1.8 | 8.5 | 0 | 0 |
| 11 | 80 | 7 | 8.8 ± 5.3 | 2.6 | 10.8 | 0 | 0 |
| 12 | 61 | 3 | 15.3 ± 3.3 | 0.37 | 4 | 3.4 | 0 |
| 13 | 80 | 11 | 6.7 ± 6.4 | 6.64 (.01) | 6.4 | 0 | 0.8 |
| 14 | 69 | 5 | 11.5 ± 4.7 | 0.37 | 4 | 0 | 0 |
| 15 | 81 | 5 | 13.5 ± 5 | 1.8 | 14.9 | 7.1 | 0 |
| 16 | 72 | 5 | 12.1 ± 5.1 | 2.18 | 7.4 | 2.0 | 0 |
| 17 | 58 | 6 | 8.3 ± 6.2 | 2.52 | 3.2 | 1.4 | 0 |
| 18 | 60 | 6 | 8.4 ± 4.7 | 1.28 | 3.2 | 0 | 0 |
| 19 | 56 | 8 | 6.2 ± 2.6 | 2.97 | 1.1 | 2.0 | 0.8 |
| Total = 1511 | Total = 138 | ||||||
| Chromosome . | Chromosome length, cM* . | No. of markers† . | Mean interval, cM ± SD‡ . | Maximum χ2 (P < .05)1-153 . | r-AML aberration incidence, %1-155 . | ||
|---|---|---|---|---|---|---|---|
| Marker . | Trisomy . | Monosomy . | |||||
| 1 | 127 | 17 | 7.1 ± 5.7 | 11.1 (.00086) | 4.0 | 6.0 | 0 |
| 2 | 114 | 10 | 10.4 ± 6.8 | 3.89 (.49) | 95 | NA | NA |
| 3 | 95 | 6 | 13.6 ± 3.4 | 0.54 | 14.9 | 0 | 2.3 |
| 4 | 84 | 10 | 7.6 ± 5.4 | 5.42 (.02) | 10.8 | 1.3 | 0 |
| 5 | 92 | 6 | 13.1 ± 2.6 | 3.36 | 8.5 | 4.0 | 0 |
| 6 | 75 | 11 | 6.3 ± 4.9 | 11.1 (.00086) | 17 | 15.0 | 1.5 |
| 7 | 74 | 5 | 12.2 ± 7.4 | 1.06 | 8.5 | 0 | 0 |
| 8 | 82 | 5 | 11.0 ± 6.0 | 1.03 | 4 | 0 | 0 |
| 9 | 74 | 5 | 12.3 ± 5.2 | 0.96 | 17 | 2.0 | 0 |
| 10 | 77 | 7 | 9.6 ± 4.4 | 1.8 | 8.5 | 0 | 0 |
| 11 | 80 | 7 | 8.8 ± 5.3 | 2.6 | 10.8 | 0 | 0 |
| 12 | 61 | 3 | 15.3 ± 3.3 | 0.37 | 4 | 3.4 | 0 |
| 13 | 80 | 11 | 6.7 ± 6.4 | 6.64 (.01) | 6.4 | 0 | 0.8 |
| 14 | 69 | 5 | 11.5 ± 4.7 | 0.37 | 4 | 0 | 0 |
| 15 | 81 | 5 | 13.5 ± 5 | 1.8 | 14.9 | 7.1 | 0 |
| 16 | 72 | 5 | 12.1 ± 5.1 | 2.18 | 7.4 | 2.0 | 0 |
| 17 | 58 | 6 | 8.3 ± 6.2 | 2.52 | 3.2 | 1.4 | 0 |
| 18 | 60 | 6 | 8.4 ± 4.7 | 1.28 | 3.2 | 0 | 0 |
| 19 | 56 | 8 | 6.2 ± 2.6 | 2.97 | 1.1 | 2.0 | 0.8 |
| Total = 1511 | Total = 138 | ||||||
Chromosome length.21
Number of chromosome-specific polymorphic microsatellite markers used.
Mean interval between markers on chromosome.
Maximum χ2 values were obtained in a test for excess homozygosity or heterozygosity in affected mice. Only values forP < .05 are shown.
Incidence (%) of clonal chromosomal aberrations in 94 to 147 mouse r-AMLs36-40 involving marker chromosomes containing translocations/deletions, trisomy, or monosomy.