Chromosomal alterations in cell cycle and apoptosis regulatory genes in B-cell lymphomas
| Lymphoma . | Gene . | Function . | Alteration . | Frequency, % . | Reference . |
|---|---|---|---|---|---|
| FL | BCL2 | Apoptosis inhibition | t(14;18) | 70-90 | Yunis et al1, Tsujimoto et al2, Cleary et al3, Weiss et al4, Yunis et al5, Tsujimoto et al6, Bakhshi et al7, Cleary et al8, and Albinger-Hegyi et al9 |
| MALT | BCL10 | Apoptosis inhibition through NF-κB | t(1;14) | Willis et al10, Zhang et al11 | |
| API2/MLT1 | t(11;18) | 50 | Levine et al12, Dierlamm et al13, Baens et al14 15, Inagaki et al16, and Liu et al17 | ||
| MCL | Cyclin D1 | G1/S cell cycle transition | t(11;14) | 90 | Tsujimoto et al18 19, Bosch et al20, and Vaandrager et al21 |
| B-CLL | ? | ? | 13q14 deletion | 50-60 | Kalachikov et al22 |
| LPL | PAX5 | B-cell differentiation | t(9;14) | 50 | Offit et al23, Iida et al24 |
| LBCL | BCL6 | B-cell activation and differentiation | t(3;N) | 30-40 | Bastard et al25, Offit et al26, and Lo Coco et al27 |
| Inflammation | |||||
| Cell cycle control | |||||
| Apoptosis inhibition | |||||
| BL | c-myc | Differentiation | t(8;14) | 80 | Boxer and Dang28, Cory29, |
| Metabolism | t(8;22) | 10 | Dalla-Favera et al30, and Taub et al31 | ||
| Cell cycle control | t(2;8) | 10 | |||
| Apoptosis induction | |||||
| Adhesion |
| Lymphoma . | Gene . | Function . | Alteration . | Frequency, % . | Reference . |
|---|---|---|---|---|---|
| FL | BCL2 | Apoptosis inhibition | t(14;18) | 70-90 | Yunis et al1, Tsujimoto et al2, Cleary et al3, Weiss et al4, Yunis et al5, Tsujimoto et al6, Bakhshi et al7, Cleary et al8, and Albinger-Hegyi et al9 |
| MALT | BCL10 | Apoptosis inhibition through NF-κB | t(1;14) | Willis et al10, Zhang et al11 | |
| API2/MLT1 | t(11;18) | 50 | Levine et al12, Dierlamm et al13, Baens et al14 15, Inagaki et al16, and Liu et al17 | ||
| MCL | Cyclin D1 | G1/S cell cycle transition | t(11;14) | 90 | Tsujimoto et al18 19, Bosch et al20, and Vaandrager et al21 |
| B-CLL | ? | ? | 13q14 deletion | 50-60 | Kalachikov et al22 |
| LPL | PAX5 | B-cell differentiation | t(9;14) | 50 | Offit et al23, Iida et al24 |
| LBCL | BCL6 | B-cell activation and differentiation | t(3;N) | 30-40 | Bastard et al25, Offit et al26, and Lo Coco et al27 |
| Inflammation | |||||
| Cell cycle control | |||||
| Apoptosis inhibition | |||||
| BL | c-myc | Differentiation | t(8;14) | 80 | Boxer and Dang28, Cory29, |
| Metabolism | t(8;22) | 10 | Dalla-Favera et al30, and Taub et al31 | ||
| Cell cycle control | t(2;8) | 10 | |||
| Apoptosis induction | |||||
| Adhesion |
LPL indicates lymphoplasmacytic lymphoma; ?; unknown.