Clinical characteristics of the 387 patients enrolled in the study
| Characteristic . | Value . |
|---|---|
| Median age at diagnosis, y (range) | 7.3 (0.1-15.6) |
| Median age at transplantation, y (range) | 7.8 (0.5-16.0) |
| Sex, M/F | 204/183 |
| FAB classification | |
| M0 | 6 |
| M1 | 59 |
| M2 | 93 |
| M3 | 36 |
| M4 | 71 |
| M5 | 96 |
| M6 | 10 |
| M7 | 16 |
| Median WBC count at diagnosis, ×109/L (range) | 17 (0.6-840) |
| Cytogenetic abnormalities | |
| Good-prognosis karyotype | 63 |
| Intermediate-risk karyotype | 102 |
| Poor-prognosis karyotype | 32 |
| Failed/unknown | 190 |
| No. induction courses to achieve first CR* | |
| 1 | 234 |
| 2 | 92 |
| 3 or more | 29 |
| Median interval diagnosis to first CR, d (range) | 38 (14-354) |
| Median interval first CR to ABMT, d (range) | 114 (17-830) |
| Source of stem cells | |
| BM | 318 |
| PB | 60 |
| BM + PB | 9 |
| Purging | |
| No | 267 |
| Yes | 120 |
| Median no. cells infused, ×108/kg (range) | |
| BM, 78 missing | 2.85 (0.2-17) |
| PB, 7 missing | 8.8 (1.95-76.5) |
| Conditioning regimen | |
| TB1 + chemotherapy | 157 |
| Busulfan + chemotherapy | 138 |
| BAVC | 37 |
| Other chemotherapy | 55 |
| Characteristic . | Value . |
|---|---|
| Median age at diagnosis, y (range) | 7.3 (0.1-15.6) |
| Median age at transplantation, y (range) | 7.8 (0.5-16.0) |
| Sex, M/F | 204/183 |
| FAB classification | |
| M0 | 6 |
| M1 | 59 |
| M2 | 93 |
| M3 | 36 |
| M4 | 71 |
| M5 | 96 |
| M6 | 10 |
| M7 | 16 |
| Median WBC count at diagnosis, ×109/L (range) | 17 (0.6-840) |
| Cytogenetic abnormalities | |
| Good-prognosis karyotype | 63 |
| Intermediate-risk karyotype | 102 |
| Poor-prognosis karyotype | 32 |
| Failed/unknown | 190 |
| No. induction courses to achieve first CR* | |
| 1 | 234 |
| 2 | 92 |
| 3 or more | 29 |
| Median interval diagnosis to first CR, d (range) | 38 (14-354) |
| Median interval first CR to ABMT, d (range) | 114 (17-830) |
| Source of stem cells | |
| BM | 318 |
| PB | 60 |
| BM + PB | 9 |
| Purging | |
| No | 267 |
| Yes | 120 |
| Median no. cells infused, ×108/kg (range) | |
| BM, 78 missing | 2.85 (0.2-17) |
| PB, 7 missing | 8.8 (1.95-76.5) |
| Conditioning regimen | |
| TB1 + chemotherapy | 157 |
| Busulfan + chemotherapy | 138 |
| BAVC | 37 |
| Other chemotherapy | 55 |
Data were missing for 32 patients.