Table 10. AAV-F.IX muscle results in 3... | American Society of Hematology

Table 10.

AAV-F.IX muscle results in 3 species

Dose, vg/kg	Mice^10-150	Dogs^10-151	Peak human
2 × 10¹¹	<1%	<0.1%	1.4%, 0.8%, <1%
6.0 × 10¹¹	<1%	0.2%	<1%, 1%, <1%
1.8 × 10¹²	1.5%	0.2%-0.4%	<1%, <1%
4.0 × 10¹²	3%	0.4%	ND
8.5 × 10¹²	ND	1.4%	ND
1.6 × 10¹³	5%-7%	ND	ND

Dose, vg/kg	Mice^10-150	Dogs^10-151	Peak human
2 × 10¹¹	<1%	<0.1%	1.4%, 0.8%, <1%
6.0 × 10¹¹	<1%	0.2%	<1%, 1%, <1%
1.8 × 10¹²	1.5%	0.2%-0.4%	<1%, <1%
4.0 × 10¹²	3%	0.4%	ND
8.5 × 10¹²	ND	1.4%	ND
1.6 × 10¹³	5%-7%	ND	ND

ND indicates not done.

See Herzog et al.22

See Herzog et al.23