Table 2.

Classes of selectable marker genes and corresponding drugs

PrincipleUtilityExample for geneDrug/agent categoryAgentReference no.
Surface tag In vitro dLNGFR Monoclonal antibody NA 120,121,123, 144-149  
Drug resistance In vitro and in vivo MGMT Cytotoxic agent Temozolomide, BCNU 137, 150-152  
  DHFR Cytotoxic agent MTX 137  
  MDR1 Cytotoxic agent Paclitaxel, etoposide 45,46,134,135,139-142  
Growth promoting In vitro and in vivo FK-mpl Chemical dimerizer AP1903 153,154  
  SAG Inducer of protein function Estrogens 155  
  HOXB4 Controlled expression required NA 51,125-131  
PrincipleUtilityExample for geneDrug/agent categoryAgentReference no.
Surface tag In vitro dLNGFR Monoclonal antibody NA 120,121,123, 144-149  
Drug resistance In vitro and in vivo MGMT Cytotoxic agent Temozolomide, BCNU 137, 150-152  
  DHFR Cytotoxic agent MTX 137  
  MDR1 Cytotoxic agent Paclitaxel, etoposide 45,46,134,135,139-142  
Growth promoting In vitro and in vivo FK-mpl Chemical dimerizer AP1903 153,154  
  SAG Inducer of protein function Estrogens 155  
  HOXB4 Controlled expression required NA 51,125-131  

This table does not provide a comprehensive overview of the genes developed as selectable markers. Its purpose is rather to show the different principles with a few selected examples. NA indicates currently not available as good manufacturing practice product.

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