Table 7. Time-varying risk factors for... | American Society of Hematology

Table 7.

Time-varying risk factors for death after day 95

Covariate	Univariate, RR	95% CI	Multivariable, RR	95% CI
CMV antigenemia, time dependent^5-152
Positive, any level	5.8	1.7, 19.6^5-150	5.0^5-155	1.5, 17.1^5-150
More than 5 positive cells/slide	7.1	2.2, 22.2^5-150	5.9^5-155	1.7, 20.4^5-150
More than 50 positive cells/slide	5.9	1.5, 22.8^5-151	—	—
More than 100 positive cells/slide	7.6	2.0, 29.3^5-150	7.2^5-155	1.5, 34.7^5-150
CMV DNA in PBL, time dependent^5-152,^5-153
0.25 log₁₀ increase	7.1	1.2, 44.2^5-150	6.4^5-155	1.0, 41.6^5-151
0.5 log₁₀increase	7.7	1.3, 46.9^5-150	6.8^5-155	1.1, 43.4^5-151
CMV DNA plasma, time dependent^5-152,^5-153
Positive, any level	11.6	1.4, 99.9^5-151	13.1^5-155	1.3, 132.7^5-151
More than 10³ copies/mL	19.7	2.3, 169.6^5-150	22.6^5-155	2.2, 227.8^5-151
CMV viremia by culture, time dependent	6.0	1.6, 22.7^5-150	—	—

Covariate	Univariate, RR	95% CI	Multivariable, RR	95% CI
CMV antigenemia, time dependent^5-152
Positive, any level	5.8	1.7, 19.6^5-150	5.0^5-155	1.5, 17.1^5-150
More than 5 positive cells/slide	7.1	2.2, 22.2^5-150	5.9^5-155	1.7, 20.4^5-150
More than 50 positive cells/slide	5.9	1.5, 22.8^5-151	—	—
More than 100 positive cells/slide	7.6	2.0, 29.3^5-150	7.2^5-155	1.5, 34.7^5-150
CMV DNA in PBL, time dependent^5-152,^5-153
0.25 log₁₀ increase	7.1	1.2, 44.2^5-150	6.4^5-155	1.0, 41.6^5-151
0.5 log₁₀increase	7.7	1.3, 46.9^5-150	6.8^5-155	1.1, 43.4^5-151
CMV DNA plasma, time dependent^5-152,^5-153
Positive, any level	11.6	1.4, 99.9^5-151	13.1^5-155	1.3, 132.7^5-151
More than 10³ copies/mL	19.7	2.3, 169.6^5-150	22.6^5-155	2.2, 227.8^5-151
CMV viremia by culture, time dependent	6.0	1.6, 22.7^5-150	—	—

— indicates results not significant

F5-150

P ≤ .01.

F5-151

P ≤ .05. See also Table 2 footnote.

F5-152

Only late-disease events up to 14 days after the last tests were included. When events until 35 days after the last test value were considered, results were qualitatively similar (data not shown).

F5-153

PCR results were tested at any positive level: greater than 10³, greater than 10⁴, greater than 10⁵, 0.25 log₁₀ and 0.5 log₁₀increases.

F5-155

For virologic parameters, each cut-off variable was entered singly in a separate model adjusting for lymphocytopenia, aspergillosis, chronic clinical-extensive GVHD, and donor CMV serostatus (CMV disease was not entered into these models).

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