Time-varying risk factors for late CMV disease after day 95
| Covariate . | Univariate, RR . | 95% CI . | Multivariable, RR . | 95% CI . |
|---|---|---|---|---|
| CMV antigenemia, time dependent4-150 | ||||
| Positive, any level | 4.0 | 1.4, 11.7‡ | 5.34-155 | 1.5, 19.1‡ |
| More than 5 cells/slide | 4.0 | 1.3, 12.1‡ | 6.14-155 | 1.7, 21.5‡ |
| More than 10 cells/slide | 4.1 | 1.3, 13.5‡ | 6.64-155 | 1.8, 24.6‡ |
| More than 50 cells/slide | 5.5 | 1.5, 20.6‡ | 8.74-155 | 2.1, 36.5‡ |
| CMV DNA in PBL, time dependent4-150,4-151 | ||||
| Positive, any level | 3.2 | 1.0, 9.94-153 | — | — |
| 0.25 log10increase | 2.3 | 1.0, 5.24-153 | — | — |
| 0.5 log10 increase | 2.4 | 1.0, 5.34-153 | — | — |
| CMV DNA plasma, time dependent4-150,4-151 | ||||
| More than 103 copies/mL | 2.1 | 0.5, 8.3 | 6.24-155 | 1.0, 39.24-153 |
| More than 104 copies/mL | 3.0 | 0.8, 12.3 | 12.34-155 | 1.8, 85.1‡ |
| Covariate . | Univariate, RR . | 95% CI . | Multivariable, RR . | 95% CI . |
|---|---|---|---|---|
| CMV antigenemia, time dependent4-150 | ||||
| Positive, any level | 4.0 | 1.4, 11.7‡ | 5.34-155 | 1.5, 19.1‡ |
| More than 5 cells/slide | 4.0 | 1.3, 12.1‡ | 6.14-155 | 1.7, 21.5‡ |
| More than 10 cells/slide | 4.1 | 1.3, 13.5‡ | 6.64-155 | 1.8, 24.6‡ |
| More than 50 cells/slide | 5.5 | 1.5, 20.6‡ | 8.74-155 | 2.1, 36.5‡ |
| CMV DNA in PBL, time dependent4-150,4-151 | ||||
| Positive, any level | 3.2 | 1.0, 9.94-153 | — | — |
| 0.25 log10increase | 2.3 | 1.0, 5.24-153 | — | — |
| 0.5 log10 increase | 2.4 | 1.0, 5.34-153 | — | — |
| CMV DNA plasma, time dependent4-150,4-151 | ||||
| More than 103 copies/mL | 2.1 | 0.5, 8.3 | 6.24-155 | 1.0, 39.24-153 |
| More than 104 copies/mL | 3.0 | 0.8, 12.3 | 12.34-155 | 1.8, 85.1‡ |
— indicates results not significant.
Only late-disease events up to 14 days after the last tests were included. When events until 35 days after the last test value were considered, results were qualitatively similar (data not shown).
PCR results were tested at any positive level: greater than 103, greater than 104, greater than 105, 0.25 log10 and 0.5 log10increases.
P ≤ .01.
P ≤ .05. See also Table 2 footnote.
For virologic parameters each cut-off variable was entered singly into separate models, adjusting for lymphocytopenia (<300/mm3) and CD4 count less than 50/mm3, both as time-varying covariates. Adjusting for CMV-specific T-cell immunity did not qualitatively change results (data not shown).