Time-varying risk factors for lymphocytopenia after day 95
| Covariate . | Univariate, RR . | 95% CI . | Multivariable, RR . | 95% CI . |
|---|---|---|---|---|
| Lymphocytopenia, time dependent | ||||
| Fewer than 100 lymphocytes/mm3 | 7.0 | 1.6, 30.56-150 | — | — |
| Fewer than 300 lymphocytes/mm3 | 7.2 | 3.1, 17.06-150 | 9.46-151 | 3.8, 23.56-150 |
| Covariate . | Univariate, RR . | 95% CI . | Multivariable, RR . | 95% CI . |
|---|---|---|---|---|
| Lymphocytopenia, time dependent | ||||
| Fewer than 100 lymphocytes/mm3 | 7.0 | 1.6, 30.56-150 | — | — |
| Fewer than 300 lymphocytes/mm3 | 7.2 | 3.1, 17.06-150 | 9.46-151 | 3.8, 23.56-150 |
— indicates results not significant.
P ≤ .01.
Candidates for the multivariable model included chronic clinical-extensive GVHD, donor type, GVHD prophylaxis, antigenemia level greater than 100 per slide before day 95, CMV-specific T-cell negativity, and CD4 lymphocyte count less than 50/mm3 (all as time-varying covariates).