Influence of selective adenosine receptor agonists on cell surface expression of membrane molecules in iDCs
| iDC . | Treatment . | |||
|---|---|---|---|---|
| None . | CHA . | DPMA . | IB-MECA . | |
| CD86 | 40.1 ± 4.62 | 39.8 ± 5.3 | 71.8 ± 4.633-150 | 73.6 ± 5.7 |
| CD80 | 32.8 ± 7.15 | 34.0 ± 6.1 | 59.8 ± 5.733-150 | 37.5 ± 5.2 |
| MHC I | 176.6 ± 48.3 | 171.4 ± 44.1 | 244.7 ± 22.53-151 | 181.1 ± 23.3 |
| HLA-DR | 171.6 ± 38.8 | 191.9 ± 39.1 | 489.9 ± 43.93-152 | 194.7 ± 43.5 |
| iDC . | Treatment . | |||
|---|---|---|---|---|
| None . | CHA . | DPMA . | IB-MECA . | |
| CD86 | 40.1 ± 4.62 | 39.8 ± 5.3 | 71.8 ± 4.633-150 | 73.6 ± 5.7 |
| CD80 | 32.8 ± 7.15 | 34.0 ± 6.1 | 59.8 ± 5.733-150 | 37.5 ± 5.2 |
| MHC I | 176.6 ± 48.3 | 171.4 ± 44.1 | 244.7 ± 22.53-151 | 181.1 ± 23.3 |
| HLA-DR | 171.6 ± 38.8 | 191.9 ± 39.1 | 489.9 ± 43.93-152 | 194.7 ± 43.5 |
Immature DCs were stimulated with 10−6 M CHA (A1 receptor agonist), 10−6 M DPMA (A2 receptor agonist), or 10−6 M IB-MECA (A3 receptor agonist) for 48 hours. The expression of the indicated molecules or isotype control was analyzed by flow cytometry. Numbers indicate the net MFI ± SEM (n = 3). Differences between cells stimulated with DPMA and with control medium:
P < .05.
P < .01.
P < .001; Tukey multiple comparison test.