A comparison of the 2 previously published studies on VL gene use in AL amyloidosis with the present data
| Germline gene . | Comenzo et al,10 . | Perfetti et al,12 . | Present data . |
|---|---|---|---|
| κ/λ | 12/48 | 0/55 | 26/32 |
| VκI | |||
| O18/O8 | 7 | — | 9 |
| O12/O2 | — | — | 4 |
| DPK 7 | 1 | — | — |
| LVFK 431 | 4 | — | 1 |
| L12/L1 | — | — | 6 |
| VκII | |||
| L5 | — | — | 1 |
| VκIV | |||
| B3 | — | — | 5 |
| VλI | |||
| Ia | 1 | — | — |
| Ib | 1 | 3 | 3 |
| Ic | 8 | 3 | 2 |
| Ie | 2 | — | 2 |
| VλII | |||
| 2a2 | 6 | 5 | 4 |
| 2b2 | — | — | 5 |
| 2c | 1 | — | 2 |
| VλIII | |||
| 3r | 7 | 12 | 9 |
| 3h | — | 6 | — |
| 3p | 1 | — | — |
| VλVI | |||
| 6a | 18 | 11 | 5 |
| Germline gene . | Comenzo et al,10 . | Perfetti et al,12 . | Present data . |
|---|---|---|---|
| κ/λ | 12/48 | 0/55 | 26/32 |
| VκI | |||
| O18/O8 | 7 | — | 9 |
| O12/O2 | — | — | 4 |
| DPK 7 | 1 | — | — |
| LVFK 431 | 4 | — | 1 |
| L12/L1 | — | — | 6 |
| VκII | |||
| L5 | — | — | 1 |
| VκIV | |||
| B3 | — | — | 5 |
| VλI | |||
| Ia | 1 | — | — |
| Ib | 1 | 3 | 3 |
| Ic | 8 | 3 | 2 |
| Ie | 2 | — | 2 |
| VλII | |||
| 2a2 | 6 | 5 | 4 |
| 2b2 | — | — | 5 |
| 2c | 1 | — | 2 |
| VλIII | |||
| 3r | 7 | 12 | 9 |
| 3h | — | 6 | — |
| 3p | 1 | — | — |
| VλVI | |||
| 6a | 18 | 11 | 5 |
The number of patients using various κ and λ germ-line donors in the 3 studies are represented. — indicates absence or lack of usage of a particular gene.