Odds ratio of venous thrombosis according to baseline D-dimer concentration, overall and in subgroups, LITE
| . | Quintile of D-dimer (range, ng/mL) . | P for trend . | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| (2.0-68.5) | (68.6-104.2) | (104.3-159.3) | (159.4-277.7) | (277.8-7428.9) | ||
| Overall venous thrombosis | ||||||
| No. of cases | 38 | 52 | 66 | 63 | 88 | <.0001 |
| No. of controls | 146 | 133 | 119 | 122 | 96 | |
| Age-adjusted | ||||||
| OR (95% CI) | 1.0 (Reference) | 1.6 (1.0-2.6) | 2.3 (1.5-3.8) | 2.3 (1.4-3.7) | 4.2 (2.6-6.8) | |
| Adjusted 1* | ||||||
| OR (95% CI) | 1.0 (Reference) | 1.5 (0.9-2.5) | 2.3 (1.4-3.7) | 2.2 (1.3-3.6) | 3.9 (2.4-6.4) | <.0001 |
| Adjusted 2† | ||||||
| OR (95% CI) | 1.0 (Reference) | 1.5 (0.9-2.5) | 2.1 (1.2-3.5) | 1.9 (1.1-3.3) | 3.0 (1.7-5.2) | <.0001 |
| Sex | ||||||
| Men | ||||||
| No. of cases | 28 | 20 | 29 | 25 | 43 | .001 |
| OR (95% CI) | 1.0 (Reference) | 0.9 (0.5-1.7) | 1.7 (0.9-3.3) | 1.7 (0.8-3.4) | 2.6 (1.4-5.1) | |
| Women | ||||||
| No. of cases | 10 | 32 | 37 | 38 | 45 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 3.4 (1.5-7.5) | 4.1 (1.9-9.0) | 4.0 (1.8-8.8) | 8.3 (3.7-18.6) | |
| Race | ||||||
| White | ||||||
| No. of cases | 32 | 41 | 53 | 47 | 60 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 1.6 (0.9-2.7) | 2.4 (1.4-4.1) | 2.4 (1.4-4.2) | 4.1 (2.4-7.2) | |
| Nonwhite | ||||||
| No. of cases | 6 | 11 | 13 | 16 | 28 | .005 |
| OR (95% CI) | 1.0 (Reference) | 1.5 (0.5-4.8) | 2.2 (0.7-7.0) | 2.1 (0.7-6.3) | 4.4 (1.5-13.0) | |
| Study | ||||||
| ARIC | ||||||
| No. of cases | 34 | 37 | 37 | 28 | 33 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 1.7 (1.0-2.9) | 2.2 (1.3-3.9) | 2.0 (1.1-3.6) | 3.4 (1.8-6.2) | |
| CHS | ||||||
| No. of cases | 4 | 15 | 29 | 35 | 55 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 1.9 (0.6-6.2) | 3.5 (1.1-11.1) | 3.7 (1.2-11.4) | 7.2 (2.3-22.1) | |
| . | Quintile of D-dimer (range, ng/mL) . | P for trend . | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| (2.0-68.5) | (68.6-104.2) | (104.3-159.3) | (159.4-277.7) | (277.8-7428.9) | ||
| Overall venous thrombosis | ||||||
| No. of cases | 38 | 52 | 66 | 63 | 88 | <.0001 |
| No. of controls | 146 | 133 | 119 | 122 | 96 | |
| Age-adjusted | ||||||
| OR (95% CI) | 1.0 (Reference) | 1.6 (1.0-2.6) | 2.3 (1.5-3.8) | 2.3 (1.4-3.7) | 4.2 (2.6-6.8) | |
| Adjusted 1* | ||||||
| OR (95% CI) | 1.0 (Reference) | 1.5 (0.9-2.5) | 2.3 (1.4-3.7) | 2.2 (1.3-3.6) | 3.9 (2.4-6.4) | <.0001 |
| Adjusted 2† | ||||||
| OR (95% CI) | 1.0 (Reference) | 1.5 (0.9-2.5) | 2.1 (1.2-3.5) | 1.9 (1.1-3.3) | 3.0 (1.7-5.2) | <.0001 |
| Sex | ||||||
| Men | ||||||
| No. of cases | 28 | 20 | 29 | 25 | 43 | .001 |
| OR (95% CI) | 1.0 (Reference) | 0.9 (0.5-1.7) | 1.7 (0.9-3.3) | 1.7 (0.8-3.4) | 2.6 (1.4-5.1) | |
| Women | ||||||
| No. of cases | 10 | 32 | 37 | 38 | 45 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 3.4 (1.5-7.5) | 4.1 (1.9-9.0) | 4.0 (1.8-8.8) | 8.3 (3.7-18.6) | |
| Race | ||||||
| White | ||||||
| No. of cases | 32 | 41 | 53 | 47 | 60 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 1.6 (0.9-2.7) | 2.4 (1.4-4.1) | 2.4 (1.4-4.2) | 4.1 (2.4-7.2) | |
| Nonwhite | ||||||
| No. of cases | 6 | 11 | 13 | 16 | 28 | .005 |
| OR (95% CI) | 1.0 (Reference) | 1.5 (0.5-4.8) | 2.2 (0.7-7.0) | 2.1 (0.7-6.3) | 4.4 (1.5-13.0) | |
| Study | ||||||
| ARIC | ||||||
| No. of cases | 34 | 37 | 37 | 28 | 33 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 1.7 (1.0-2.9) | 2.2 (1.3-3.9) | 2.0 (1.1-3.6) | 3.4 (1.8-6.2) | |
| CHS | ||||||
| No. of cases | 4 | 15 | 29 | 35 | 55 | <.0001 |
| OR (95% CI) | 1.0 (Reference) | 1.9 (0.6-6.2) | 3.5 (1.1-11.1) | 3.7 (1.2-11.4) | 7.2 (2.3-22.1) | |