Calcium ionophore A23187 exerts no profound effects on microhemodynamic parameters
| Parameter . | Baseline . | Ionophore . |
|---|---|---|
| Vessel diameter, μm | ||
| Controls | 20.4 ± 0.8 | 20.3 ± 0.5 |
| LLC-1 | 22.0 ± 0.5* | 22.3 ± 1.2* |
| BFS-1 | 20.0 ± 0.8† | 19.3 ± 0.2*,† |
| RBC velocity, mm/s | ||
| Controls | 0.33 ± 0.03 | 0.3 ± 0.06 |
| LLC-1 | 0.28 ± 0.02* | 0.23 ± 0.02* |
| BFS-1 | 0.25 ± 0.08* | 0.25 ± 0.02* |
| Wall shear rate, s−1 | ||
| Controls | 126.9 ± 13.8 | 119.7 ± 19.6 |
| LLC-1 | 98.5 ± 8.3* | 82.9 ± 4.7* |
| BFS-1 | 93.8 ± 9.3* | 103.7 ± 9.4† |
| Parameter . | Baseline . | Ionophore . |
|---|---|---|
| Vessel diameter, μm | ||
| Controls | 20.4 ± 0.8 | 20.3 ± 0.5 |
| LLC-1 | 22.0 ± 0.5* | 22.3 ± 1.2* |
| BFS-1 | 20.0 ± 0.8† | 19.3 ± 0.2*,† |
| RBC velocity, mm/s | ||
| Controls | 0.33 ± 0.03 | 0.3 ± 0.06 |
| LLC-1 | 0.28 ± 0.02* | 0.23 ± 0.02* |
| BFS-1 | 0.25 ± 0.08* | 0.25 ± 0.02* |
| Wall shear rate, s−1 | ||
| Controls | 126.9 ± 13.8 | 119.7 ± 19.6 |
| LLC-1 | 98.5 ± 8.3* | 82.9 ± 4.7* |
| BFS-1 | 93.8 ± 9.3* | 103.7 ± 9.4† |
Experiments were performed on highly vascularized tumors 14 days after tumor cell implantation and on subcutaneous venules within tumor-free chamber preparations of controls. Data are given as the median ± standard error of the median; n = 6 experimental animals per group. P values are according to the Kruskal-Wallis test.
P < .05 versus controls.
P < .05 versus LLC-1.