Table 2.

Causes of mortality to day 300, reduced-intensity allografts

Reduced-intensity conditioning
SiblingVUDAll
Days 0 to 100 Total = 6, TRM = 2 Total = 5, TRM = 4 Total = 11, TRM = 6  
 Relapse/progressive disease 4 1 5  
 Primary graft failure* 0 1 1 
 Parainfluenza III pneumonitis* 1 0 1  
 Bacterial sepsis* 1 2 3  
 Perforated viscus* 0 1 1  
Days 101 to 200 Total = 4, TRM = 1 Total = 7, TRM = 6 Total = 11, TRM = 7  
 Relapse 3 1 4 
 Thrombotic thrombocytopenic 1 0 1 
 purpura* 0 1 1  
 Bacterial bronchopneumonia* 0 1 1  
 PTLD* 0 1 1  
 CMV pneumonitis* 0 1 1  
 Adenovirus infection* 0 1 1 
 Parainfluenza III pneumonitis* 0 1 1  
 Late graft failure*    
Days 201 to 300 Total = 2, TRM = 1 Total = 2, TRM = 1 Total = 4, TRM = 1  
 Relapse 1 1 2  
 RSV pneumonitis* 0 1 1  
 Bacterial pneumonia* 1 0 1 
Reduced-intensity conditioning
SiblingVUDAll
Days 0 to 100 Total = 6, TRM = 2 Total = 5, TRM = 4 Total = 11, TRM = 6  
 Relapse/progressive disease 4 1 5  
 Primary graft failure* 0 1 1 
 Parainfluenza III pneumonitis* 1 0 1  
 Bacterial sepsis* 1 2 3  
 Perforated viscus* 0 1 1  
Days 101 to 200 Total = 4, TRM = 1 Total = 7, TRM = 6 Total = 11, TRM = 7  
 Relapse 3 1 4 
 Thrombotic thrombocytopenic 1 0 1 
 purpura* 0 1 1  
 Bacterial bronchopneumonia* 0 1 1  
 PTLD* 0 1 1  
 CMV pneumonitis* 0 1 1  
 Adenovirus infection* 0 1 1 
 Parainfluenza III pneumonitis* 0 1 1  
 Late graft failure*    
Days 201 to 300 Total = 2, TRM = 1 Total = 2, TRM = 1 Total = 4, TRM = 1  
 Relapse 1 1 2  
 RSV pneumonitis* 0 1 1  
 Bacterial pneumonia* 1 0 1 

There were no deaths attributable to GVHD.

PTLD indicates posttransplantation lymphoproliferative disorder; and VOD, veno-occlusive disease.

*

Indicates TRM.

View Large