Multivariate regression results in TTI (n = 222)
| . | Overall survival . | Event-free survival . | ||
|---|---|---|---|---|
| Prognostic variables . | HR (95% CI) . | P4-150 . | HR (95% CI) . | P4-150 . |
| Results for specific pretherapy CAs | ||||
| del(20) | 2.86 (1.3, 6.5) | .012 | — | NS |
| del(8) | — | NS | 3.08 (1.5, 6.3) | .002 |
| Hypodiploid or CA 13 | 2.32 (1.5, 3.5) | < .001 | 1.82 (1.2, 2.7) | .002 |
| Results for specific pretherapy CAs and standard prognostic factors | ||||
| del 8 | — | NS | 3.61 (1.6, 8.4) | .003 |
| Hypodiploid or CA 13 | 2.33 (1.5, 3.5) | < .001 | 1.79 (1.2, 2.7) | .006 |
| CRP level at least 4 mg/L | 1.50 (1.0, 2.2) | .031 | 1.59 (1.1, 2.2) | .006 |
| LDH level at least 190 U/L | 1.70 (1.1, 2.6) | .013 | — | NS |
| Creatinine level above 176.8 μM | 2.52 (1.4, 4.6) | .002 | — | NS |
| B2M level at least 345 nM | — | NS | 1.46 (1.0, 2.1) | .036 |
| Results for specific pretherapy CAs, standard prognostic factors, and time-dependent covariates | ||||
| Time-dependent CR | 0.53 (0.32, 0.86) | .011 | — | NS |
| Time to CR, mo | 1.08 (1.04, 1.01) | < .001 | — | NS |
| Time-dependent relapse | 8.42 (5.26, 3.5) | < .001 | — | NS |
| Time-dependent hypodiploid or CA 13 | 2.75 (1.94, 3.88) | < .001 | 1.39 (1.01, 1.90) | .041 |
| Time-dependent TX2 | — | NS | 0.66 (0.44, 0.99) | .025 |
| CRP level at least 4 mg/L | 1.58 (1.12, 2.23) | .010 | 1.52 (1.12, 2.06) | .007 |
| Creatinine level above 176.8 μM | 1.91 (1.14, 3.22) | .014 | — | NS |
| B2M level at least 345 nM | — | NS | 1.66 (1.20, 2.30) | .002 |
| . | Overall survival . | Event-free survival . | ||
|---|---|---|---|---|
| Prognostic variables . | HR (95% CI) . | P4-150 . | HR (95% CI) . | P4-150 . |
| Results for specific pretherapy CAs | ||||
| del(20) | 2.86 (1.3, 6.5) | .012 | — | NS |
| del(8) | — | NS | 3.08 (1.5, 6.3) | .002 |
| Hypodiploid or CA 13 | 2.32 (1.5, 3.5) | < .001 | 1.82 (1.2, 2.7) | .002 |
| Results for specific pretherapy CAs and standard prognostic factors | ||||
| del 8 | — | NS | 3.61 (1.6, 8.4) | .003 |
| Hypodiploid or CA 13 | 2.33 (1.5, 3.5) | < .001 | 1.79 (1.2, 2.7) | .006 |
| CRP level at least 4 mg/L | 1.50 (1.0, 2.2) | .031 | 1.59 (1.1, 2.2) | .006 |
| LDH level at least 190 U/L | 1.70 (1.1, 2.6) | .013 | — | NS |
| Creatinine level above 176.8 μM | 2.52 (1.4, 4.6) | .002 | — | NS |
| B2M level at least 345 nM | — | NS | 1.46 (1.0, 2.1) | .036 |
| Results for specific pretherapy CAs, standard prognostic factors, and time-dependent covariates | ||||
| Time-dependent CR | 0.53 (0.32, 0.86) | .011 | — | NS |
| Time to CR, mo | 1.08 (1.04, 1.01) | < .001 | — | NS |
| Time-dependent relapse | 8.42 (5.26, 3.5) | < .001 | — | NS |
| Time-dependent hypodiploid or CA 13 | 2.75 (1.94, 3.88) | < .001 | 1.39 (1.01, 1.90) | .041 |
| Time-dependent TX2 | — | NS | 0.66 (0.44, 0.99) | .025 |
| CRP level at least 4 mg/L | 1.58 (1.12, 2.23) | .010 | 1.52 (1.12, 2.06) | .007 |
| Creatinine level above 176.8 μM | 1.91 (1.14, 3.22) | .014 | — | NS |
| B2M level at least 345 nM | — | NS | 1.66 (1.20, 2.30) | .002 |
HR indicates hazard ratio; 95% CI, 95% confidence interval; NS, not significant; TX2, second transplant; and —, not applicable.
Based on regression model.