Disease response and changes in Bcl-2 mRNA and proteins at day 5 of the G3139 CIVI
| UPN . | Response to G3139 plus FLAG . | Baseline BM blast percentage . | BM Bcl-2 copies per nanogram of RNA . | % changes in Bcl-2 mRNA level by day 5 of G3139 CIVI . | % changes in Bcl-2 protein level by day 5 of G3139 CIVI . | |
|---|---|---|---|---|---|---|
| Day 1 . | Day 5 . | |||||
| 1 | CR | 99 | 8 100 | 11 210 | +38.4 | +6.0 |
| 3 | NR | 71 | 2 246 | 1 956 | −12.9 | NA |
| 4 | CR | 62 | 4 126 | 1 869 | −54.7 | NA |
| 5 | IR | 94 | 2 199 | 534 | −75.7 | −71.2 |
| 7 | CR | 21 | 5 212 | 3 299 | −36.75-150 | −79.4 |
| 8 | IR | 7 | 8 186 | 9 913 | +21.1 | +33.1 |
| 10 | NR | 94 | 2 737 | 3 657 | +33.6 | NA |
| 12 | NR | 80 | 23 299 | 10 264 | −55.9 | NA |
| 14 | NR | 25 | 5 749 | 3 317 | −42.3 | +38.7 |
| 18 | NR | 12 | 3 843 | 2 271 | −40.9 | NA |
| 19 | NR | 58 | 26 902 | 17 728 | −34.1 | NA |
| 20 | NR | 90 | 18 914 | 17 684 | −6.5 | NA |
| UPN . | Response to G3139 plus FLAG . | Baseline BM blast percentage . | BM Bcl-2 copies per nanogram of RNA . | % changes in Bcl-2 mRNA level by day 5 of G3139 CIVI . | % changes in Bcl-2 protein level by day 5 of G3139 CIVI . | |
|---|---|---|---|---|---|---|
| Day 1 . | Day 5 . | |||||
| 1 | CR | 99 | 8 100 | 11 210 | +38.4 | +6.0 |
| 3 | NR | 71 | 2 246 | 1 956 | −12.9 | NA |
| 4 | CR | 62 | 4 126 | 1 869 | −54.7 | NA |
| 5 | IR | 94 | 2 199 | 534 | −75.7 | −71.2 |
| 7 | CR | 21 | 5 212 | 3 299 | −36.75-150 | −79.4 |
| 8 | IR | 7 | 8 186 | 9 913 | +21.1 | +33.1 |
| 10 | NR | 94 | 2 737 | 3 657 | +33.6 | NA |
| 12 | NR | 80 | 23 299 | 10 264 | −55.9 | NA |
| 14 | NR | 25 | 5 749 | 3 317 | −42.3 | +38.7 |
| 18 | NR | 12 | 3 843 | 2 271 | −40.9 | NA |
| 19 | NR | 58 | 26 902 | 17 728 | −34.1 | NA |
| 20 | NR | 90 | 18 914 | 17 684 | −6.5 | NA |
BM indicates bone marrow; CR, complete remission; NR, no response; NA, not available; and IR, incomplete remission (see “Eligibility criteria and study design” for definition).
Percentage of change at day 5 of G3139 CIVI.