Pharmacokinetic parameters for G3139 given at 4 and 7 mg/kg CIVI
| Patient UPN . | No. of courses . | AUC0−, μg · h/mL . | Css, μg/mL . | CL, L/h . | Kel, h−1 . | t1/2, h . | V, L . |
|---|---|---|---|---|---|---|---|
| 4 mg/kg, average ± SD (range) | 12 | 856 ± 361 | 3.19 ± 1.29 | 4.35 ± 1.85 | 1.10 ± 0.55 | 0.63 ± 0.33 (0.36-1.80) | 7.45 ± 4.91 |
| 7 mg/kg, average ± SD (range) | 6 | 1546 ± 659 | 5.47 ± 2.16 | 3.89 ± 1.48 | 1.32 ± 0.56 | 0.52 ± 0.23 (0.33-1.13) | 4.70 ± 4.27 |
| Total4-150 | 18 | — | — | 4.20 ± 1.71 | 1.18 ± 0.54 | 0.59 ± 0.27 | — |
| Patient UPN . | No. of courses . | AUC0−, μg · h/mL . | Css, μg/mL . | CL, L/h . | Kel, h−1 . | t1/2, h . | V, L . |
|---|---|---|---|---|---|---|---|
| 4 mg/kg, average ± SD (range) | 12 | 856 ± 361 | 3.19 ± 1.29 | 4.35 ± 1.85 | 1.10 ± 0.55 | 0.63 ± 0.33 (0.36-1.80) | 7.45 ± 4.91 |
| 7 mg/kg, average ± SD (range) | 6 | 1546 ± 659 | 5.47 ± 2.16 | 3.89 ± 1.48 | 1.32 ± 0.56 | 0.52 ± 0.23 (0.33-1.13) | 4.70 ± 4.27 |
| Total4-150 | 18 | — | — | 4.20 ± 1.71 | 1.18 ± 0.54 | 0.59 ± 0.27 | — |
All parameters are mean ± SD.
AUC0− indicates area under the plasma concentration-time curve calculated by linear trapezoid rule with actual data plus extrapolated data; Css, plasma steady-state concentration; CL, the total body clearance; Kel, elimination rate constant; t1/2, plasma elimination phase half-life with harmonic mean half-life and its SD; V, volume of distribution calculated by model fitting; —, not applicable.
Because all pharmacokinetic parameters are linear with dose, the appropriate mean values were computed for all patients.