Comparison of response to anti-IgD and anti-CD79α in anti-IgM nonresponsive CLL
| Patient no. . | Syk phosphorylation with anti-IgM . | Syk phosphorylation with anti-IgD . | Syk phosphorylation with anti-CD79α . |
|---|---|---|---|
| 4 | + | ND | + |
| 7 | + | + | + |
| 11 | + | ND | + |
| 12 | + | ND | + |
| 16 | − | − | − |
| 18 | + | + | + |
| 25 | − | − | + |
| 26 | − | + | + |
| 27 | − | + | + |
| 28 | − | + | + |
| 29 | − | + | + |
| 30 | − | + | + |
| 31 | − | ND | + |
| 33 | − | + | + |
| 34 | − | − | − |
| 35 | − | + | ND |
| 36 | − | − | + |
| 37 | − | + | + |
| 38 | − | − | − |
| 39 | − | + | + |
| 40 | − | + | + |
| Patient no. . | Syk phosphorylation with anti-IgM . | Syk phosphorylation with anti-IgD . | Syk phosphorylation with anti-CD79α . |
|---|---|---|---|
| 4 | + | ND | + |
| 7 | + | + | + |
| 11 | + | ND | + |
| 12 | + | ND | + |
| 16 | − | − | − |
| 18 | + | + | + |
| 25 | − | − | + |
| 26 | − | + | + |
| 27 | − | + | + |
| 28 | − | + | + |
| 29 | − | + | + |
| 30 | − | + | + |
| 31 | − | ND | + |
| 33 | − | + | + |
| 34 | − | − | − |
| 35 | − | + | ND |
| 36 | − | − | + |
| 37 | − | + | + |
| 38 | − | − | − |
| 39 | − | + | + |
| 40 | − | + | + |
Responses of selected mutated CLL samples to anti-IgM, anti-IgD, and anti-CD79α determined by induced Syk phosphorylation are shown. ND indicates not determined; +, greater than 2-fold increase in Syk phosphorylation; −, less than 2-fold increase in Syk phosphorylation.