Expected major cytogenetic response rate by the presence or absence of poor prognostic factors
| Prognostic factors . | n . | Major cytogenetic response, n (%) . |
|---|---|---|
| Chronic phase CML5-150 | ||
| 0-1 | 102 | 94 (92) |
| 2 | 167 | 100 (60) |
| 3 | 51 | 17 (33) |
| 4 | 14 | 1 (7) |
| Accelerated phase CML5-151 | ||
| 0 | 50 | 31 (62) |
| 1 | 64 | 18 (28) |
| 2 | 19 | 1 (5) |
| Prognostic factors . | n . | Major cytogenetic response, n (%) . |
|---|---|---|
| Chronic phase CML5-150 | ||
| 0-1 | 102 | 94 (92) |
| 2 | 167 | 100 (60) |
| 3 | 51 | 17 (33) |
| 4 | 14 | 1 (7) |
| Accelerated phase CML5-151 | ||
| 0 | 50 | 31 (62) |
| 1 | 64 | 18 (28) |
| 2 | 19 | 1 (5) |
Poor prognostic factors were marrow blast 5% or more, duration of CML 1 year or longer, percentage of Ph+ at start of therapy greater than 90%, and prior IFN-α response (hematologic resistance–refractory).
Poor prognostic factors were splenomegaly 10 cm or more, below coastal margin, longer duration of CML disease more than 3 years.