Table 1.

Comparison of 131I and 90Y radioimmunoconjugates

131I tositumomab90Y ibritumomab tiuxetan
γ emission Yes No  
β emission 0.81 MeV 2.3 MeV  
Path length 0.8 mm 5 mm 
Half-life 8.0 d 2.7 d  
Biologic clearance Rapid Slower  
Nontumor distribution Thyroid Bone  
Imaging Yes No 
Dosing Whole body clearance Per body weight 
131I tositumomab90Y ibritumomab tiuxetan
γ emission Yes No  
β emission 0.81 MeV 2.3 MeV  
Path length 0.8 mm 5 mm 
Half-life 8.0 d 2.7 d  
Biologic clearance Rapid Slower  
Nontumor distribution Thyroid Bone  
Imaging Yes No 
Dosing Whole body clearance Per body weight 
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