Characteristics of leukemias induced by MLL fusion proteins
| . | Latency, d . | WBC counts, 106/mL . | Blasts in PB, % . | Spleen weight, g . | Liver weight, g . |
|---|---|---|---|---|---|
| Control | N/A | 6.9 ± 1.2 | 0 ± 0 | 0.12 ± 0.03 | 0.45 ± 0.12 |
| MLL-FKHRL1* | 157 ± 70 | 11.7 ± 8.3 | 2 ± 1 | 0.4 ± 0.11 | 0.94 ± 0.21 |
| MLL-AFX* | 185 ± 115 | 10.7 ± 7.3 | 5 ± 2 | 0.5 ± 0.13 | 1.13 ± 0.28 |
| MLL-AF10* | 52 ± 8 | 222 ± 94 | 54 ± 24 | 1.80 ± 0.24 | 2.25 ± 0.45 |
| . | Latency, d . | WBC counts, 106/mL . | Blasts in PB, % . | Spleen weight, g . | Liver weight, g . |
|---|---|---|---|---|---|
| Control | N/A | 6.9 ± 1.2 | 0 ± 0 | 0.12 ± 0.03 | 0.45 ± 0.12 |
| MLL-FKHRL1* | 157 ± 70 | 11.7 ± 8.3 | 2 ± 1 | 0.4 ± 0.11 | 0.94 ± 0.21 |
| MLL-AFX* | 185 ± 115 | 10.7 ± 7.3 | 5 ± 2 | 0.5 ± 0.13 | 1.13 ± 0.28 |
| MLL-AF10* | 52 ± 8 | 222 ± 94 | 54 ± 24 | 1.80 ± 0.24 | 2.25 ± 0.45 |
WBC indicates white blood cell; PB, peripheral blood; and N/A, not applicable.
Values shown are the mean (± SEM) from MLL-FKHRL1 (n = 6), MLL-AFX (n = 10), and MLL-AF10 (n = 10) mice at the time mice were killed.