Inhibition of radioiron uptake (% untreated controls)
| Chelator concentration μM . | (n) . | 20 . | 40 . | 80 . | 160 . | 320 . |
|---|---|---|---|---|---|---|
| DFO | (6) | 79.3 ± 0.5 | 75.9 ± 5.9 | 32.4 ± 8.8 | 0.7 ± 0.2 | 0.9 ± 0.3 |
| 101 (PBH) | (4) | 96.1 ± 10.7 | 109.0 ± 12.2 | 80.1 ± 9.0 | 58.1 ± 11.1 | 26.9 ± 5.0 |
| 108-o | (4) | 92.8 ± 12.1 | 87.2 ± 8.6 | 78.4 ± 5.9 | 49.5 ± 4.2 | 7.8 ± 0.8 |
| 108-p | (4) | 99.5 ± 6.3 | 97.9 ± 15.9 | 83.7 ± 9.7 | 121.3 ± 8.5 | 153.7 ± 0.8 |
| 109-o | (4) | 99.4 ± 14.0 | 106.6 ± 10.1 | 84.6 ± 12.9 | 76.2 ± 10.0 | 50.8 ± 4.9 |
| 109-p | (4) | 107.8 ± 4.9 | 96.1 ± 1.9 | 87.8 ± 8.2 | 63.9 ± 6.0 | 25.8 ± 1.6 |
| 111 (PIH) | (4) | 89.8 ± 7.0 | 76.7 ± 30.7 | 73.2 ± 1.2 | 36.1 ± 1.1 | 4.8 ± 0.4 |
| 208-o | (4) | 100.8 ± 8.4 | 115.4 ± 11.9 | 110.6 ± 10.8 | 106.6 ± 2.2 | 41.9 ± 5.8 |
| 208-p | (4) | 106.8 ± 5.4 | 101.4 ± 10.1 | 112.5 ± 11.8 | 124.4 ± 2.9 | 126.6 ± 11.0 |
| 211 (SIH) | (4) | 91.0 ± 6.8 | 86.6 ± 10.6 | 74.6 ± 10.4 | 63.9 ± 2.8 | 10.3 ± 10.7 |
| 301 | (4) | 104.5 ± 2.9 | 103.3 ± 19.3 | 88.6 ± 11.9 | 125.1 ± 5.2 | 132.5 ± 10.9 |
| 308 | (4) | 94.4 ± 1.4 | 107.5 ± 1.6 | 86.1 ± 13.6 | 108.8 ± 9.2 | 106.5 ± 11.0 |
| 309 | (4) | 86.2 ± 2.0 | 97.9 ± 3.8 | 100.3 ± 5.3 | 103.5 ± 9.2 | 98.5 ± 5.8 |
| 311 | (4) | 86.5 ± 5.9 | 84.0 ± 7.2 | 107.0 ± 3.8 | 115.9 ± 8.8 | 114.6 ± 9.0 |
| 315 | (4) | 84.1 ± 2.7 | 97.0 ± 3.3 | 97.9 ± 4.6 | 101.9 ± 3.8 | 91.3 ± 1.2 |
| Chelator concentration μM . | (n) . | 20 . | 40 . | 80 . | 160 . | 320 . |
|---|---|---|---|---|---|---|
| DFO | (6) | 79.3 ± 0.5 | 75.9 ± 5.9 | 32.4 ± 8.8 | 0.7 ± 0.2 | 0.9 ± 0.3 |
| 101 (PBH) | (4) | 96.1 ± 10.7 | 109.0 ± 12.2 | 80.1 ± 9.0 | 58.1 ± 11.1 | 26.9 ± 5.0 |
| 108-o | (4) | 92.8 ± 12.1 | 87.2 ± 8.6 | 78.4 ± 5.9 | 49.5 ± 4.2 | 7.8 ± 0.8 |
| 108-p | (4) | 99.5 ± 6.3 | 97.9 ± 15.9 | 83.7 ± 9.7 | 121.3 ± 8.5 | 153.7 ± 0.8 |
| 109-o | (4) | 99.4 ± 14.0 | 106.6 ± 10.1 | 84.6 ± 12.9 | 76.2 ± 10.0 | 50.8 ± 4.9 |
| 109-p | (4) | 107.8 ± 4.9 | 96.1 ± 1.9 | 87.8 ± 8.2 | 63.9 ± 6.0 | 25.8 ± 1.6 |
| 111 (PIH) | (4) | 89.8 ± 7.0 | 76.7 ± 30.7 | 73.2 ± 1.2 | 36.1 ± 1.1 | 4.8 ± 0.4 |
| 208-o | (4) | 100.8 ± 8.4 | 115.4 ± 11.9 | 110.6 ± 10.8 | 106.6 ± 2.2 | 41.9 ± 5.8 |
| 208-p | (4) | 106.8 ± 5.4 | 101.4 ± 10.1 | 112.5 ± 11.8 | 124.4 ± 2.9 | 126.6 ± 11.0 |
| 211 (SIH) | (4) | 91.0 ± 6.8 | 86.6 ± 10.6 | 74.6 ± 10.4 | 63.9 ± 2.8 | 10.3 ± 10.7 |
| 301 | (4) | 104.5 ± 2.9 | 103.3 ± 19.3 | 88.6 ± 11.9 | 125.1 ± 5.2 | 132.5 ± 10.9 |
| 308 | (4) | 94.4 ± 1.4 | 107.5 ± 1.6 | 86.1 ± 13.6 | 108.8 ± 9.2 | 106.5 ± 11.0 |
| 309 | (4) | 86.2 ± 2.0 | 97.9 ± 3.8 | 100.3 ± 5.3 | 103.5 ± 9.2 | 98.5 ± 5.8 |
| 311 | (4) | 86.5 ± 5.9 | 84.0 ± 7.2 | 107.0 ± 3.8 | 115.9 ± 8.8 | 114.6 ± 9.0 |
| 315 | (4) | 84.1 ± 2.7 | 97.0 ± 3.3 | 97.9 ± 4.6 | 101.9 ± 3.8 | 91.3 ± 1.2 |