Stratified Cox model of the relevant morphologic factors together with clinical factors (stage, B symptoms, IPS)
| Factors in score . | PFS . | OS . | ||
|---|---|---|---|---|
| HR . | CI . | HR . | CI . | |
| EOS + LYM + MOR + NEC | 1.60 | 1.18-2.17 | 2.70 | 1.70-4.29 |
| EOS + MOR + NEC | 1.60 | 1.18-2.16 | 2.76 | 1.75-4.35 |
| EOS + LYM + NEC | 1.48 | 1.10-2.00 | 2.53 | 1.63-3.92 |
| EOS + LYM + MOR3-150 | 1.73 | 1.29-2.32 | 2.83 | 1.83-4.37 |
| EOS + MOR | 1.71 | 1.28-2.30 | 2.81 | 1.84-4.29 |
| EOS + LYM | 1.62 | 1.21-2.16 | 2.77 | 1.83-4.18 |
| EOS + NEC | 1.44 | 1.08-1.93 | 2.50 | 1.63-3.84 |
| EOS | 1.57 | 1.18-2.09 | 2.78 | 1.86-4.16 |
| Factors in score . | PFS . | OS . | ||
|---|---|---|---|---|
| HR . | CI . | HR . | CI . | |
| EOS + LYM + MOR + NEC | 1.60 | 1.18-2.17 | 2.70 | 1.70-4.29 |
| EOS + MOR + NEC | 1.60 | 1.18-2.16 | 2.76 | 1.75-4.35 |
| EOS + LYM + NEC | 1.48 | 1.10-2.00 | 2.53 | 1.63-3.92 |
| EOS + LYM + MOR3-150 | 1.73 | 1.29-2.32 | 2.83 | 1.83-4.37 |
| EOS + MOR | 1.71 | 1.28-2.30 | 2.81 | 1.84-4.29 |
| EOS + LYM | 1.62 | 1.21-2.16 | 2.77 | 1.83-4.18 |
| EOS + NEC | 1.44 | 1.08-1.93 | 2.50 | 1.63-3.84 |
| EOS | 1.57 | 1.18-2.09 | 2.78 | 1.86-4.16 |
Hazard ratios for the division of patients into 2 groups based on various prognostic scores. For each score, the patients are divided into those having at least one of the adverse factors included (listed in the first column) versus those having none of these factors. Hazard ratios are based on a Cox proportional hazards model including the score in question together with the clinical cofactors stage, B symptoms, and the IPFP prognostic score (IPS). Large hazard ratios imply greater prognostic separation between the 2 groups. EOS indicates eosinophilia; LYM, lymphocyte depletion; MOR, morphologic atypia; NEC, necrosis.
3-factor model separating best patients doing well and doing poorly.