Table 1. Significance of the histologic... | American Society of Hematology

Table 1.

Significance of the histologic parameters in NS by univariate analysis

Histomorphologic parameter	OS, P	PFS, P
Sclerotic thickening of the lymph node capsule^*	≥ .2	≥ .2
Sclerotic bands within the lymph node^†	.13	≥ .2
Partial or total involvement of the lymph node by the neoplastic and inflammatory cells^‡	≥ .2	≥ .2
Cohesive clusters or sheets of the H/RS cells^1-153	.10	≥ .2
Tissue infiltration by neutrophils^1-155	≥ .2	≥ .2
Presence of coagulative necrosis^1-154	.02^1-161	≥ .2
Morphologic atypia of the H/RS cells#	.13	.008^1-161
Relative amount of lymphocytes^1-160	.003^1-161	.07^1-161
Tissue infiltration by eosinophils^1-164	≤ .0001^1-161	.002^1-161

Histomorphologic parameter	OS, P	PFS, P
Sclerotic thickening of the lymph node capsule^*	≥ .2	≥ .2
Sclerotic bands within the lymph node^†	.13	≥ .2
Partial or total involvement of the lymph node by the neoplastic and inflammatory cells^‡	≥ .2	≥ .2
Cohesive clusters or sheets of the H/RS cells^1-153	.10	≥ .2
Tissue infiltration by neutrophils^1-155	≥ .2	≥ .2
Presence of coagulative necrosis^1-154	.02^1-161	≥ .2
Morphologic atypia of the H/RS cells#	.13	.008^1-161
Relative amount of lymphocytes^1-160	.003^1-161	.07^1-161
Tissue infiltration by eosinophils^1-164	≤ .0001^1-161	.002^1-161

Less than versus more than 1 mm in diameter on the microscopic glass slide.

†

Less than versus more than 50% of the lymph node tissue.

‡

Total involvement versus focal residual secondary follicles.

F1-153

No syncytia or small clusters versus syncytia (sheets of > 20 cohesive H/RS cells).

F1-155

No or few neutrophils versus neutrophils approximately more than 15% of all cells.

F1-154

No or fewer than 3 small foci of necrosis versus large areas of necrosis.

#Typical H/RS cells and variants versus numerous atypical cells (> 25% bizarre and highly anaplastic-appearing H/RS cells with pleomorphic nuclear features, hyperchromatism, and highly irregular nuclear outlines, according to MacLennan et al8).

F1-160

Lymphocytes more versus less than 33% of all cells in the whole section.

F1-164

Eosinophilia (> 5% of all cells or clusters in at least 5 high-power fields) versus no eosinophilia, according to von Wasielewski et al.19

F1-161

Significant and borderline significant P values(P < .10).

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