Clinical and cytogenetical features of the MDS patients
| Age/ sex . | Diagnosis . | Karyotype . | Distance from hypocenter of atomic bomb . | AML1 mutation . | Case no. . | |
|---|---|---|---|---|---|---|
| cDNA . | Protein . | |||||
| 66/F | MDS (RA) | 46, XX | + (2.5 km) | 471G>T | Pro157syn | 1 |
| 81/F | MDS (RAEBt) | 45, XX, −5 | + (2.0 km) | 303T>C | Thr101syn | 2 |
| 69/M | MDS (RAEBt) | 46, XY, del(12)(p12), der(14)t(1;14)(p10;p10) | + (2.7 km) | 124G>C | Gly42Arg | 3 |
| 59/F | MDS (RAEBt) | 46, XX, del(3)(p14) | + (1.7 km) | 208delC | Ser70fsTer93 | 4 |
| 68/M | MDS (RAEBt) | 47, XY, t(3;5)(q27;p13), +4, +5, −7 | + (0.8 km) | 511G>A | Asp171Asn | 5 |
| 80/F | MDS→AML (M4) | 47, XX, +8, t(9;11)(q22;q23) | + (2.5 km) | 124G>C | Gly42Arg | 6 |
| 75/F | MDS (RA) | 46, XX, del(11)(q21) | + (2.2 km) | WT | WT | — |
| 70/M | MDS (RA) | 46, XY | + (1.0 km) | WT | WT | — |
| 69/F | MDS (RA) | 46, XX | + (2.8 km) | WT | WT | — |
| 78/F | MDS (RAEB) | 46, XX, add(1)(p11), del(11)(q21) | + (1.7 km) | WT | WT | — |
| 80/M | MDS (RAEBt) | 46, XY | + (0.8 km) | WT | WT | — |
| 70/M | MDS (RAEBt) | 46, XY | + (2.0 km) | WT | WT | — |
| 69/M | MDS (RAEBt) | 46, XY | + (1.5 km) | WT | WT | — |
| 80/M | MDS (RAEBt) | 46, XY | −* | 316_338dup | Tyr113Ter | 7 |
| 43/F | MDS (RAEBt) | 45, XX, −7 | − | 511G>A | Asp171Asn | 8 |
| Age/ sex . | Diagnosis . | Karyotype . | Distance from hypocenter of atomic bomb . | AML1 mutation . | Case no. . | |
|---|---|---|---|---|---|---|
| cDNA . | Protein . | |||||
| 66/F | MDS (RA) | 46, XX | + (2.5 km) | 471G>T | Pro157syn | 1 |
| 81/F | MDS (RAEBt) | 45, XX, −5 | + (2.0 km) | 303T>C | Thr101syn | 2 |
| 69/M | MDS (RAEBt) | 46, XY, del(12)(p12), der(14)t(1;14)(p10;p10) | + (2.7 km) | 124G>C | Gly42Arg | 3 |
| 59/F | MDS (RAEBt) | 46, XX, del(3)(p14) | + (1.7 km) | 208delC | Ser70fsTer93 | 4 |
| 68/M | MDS (RAEBt) | 47, XY, t(3;5)(q27;p13), +4, +5, −7 | + (0.8 km) | 511G>A | Asp171Asn | 5 |
| 80/F | MDS→AML (M4) | 47, XX, +8, t(9;11)(q22;q23) | + (2.5 km) | 124G>C | Gly42Arg | 6 |
| 75/F | MDS (RA) | 46, XX, del(11)(q21) | + (2.2 km) | WT | WT | — |
| 70/M | MDS (RA) | 46, XY | + (1.0 km) | WT | WT | — |
| 69/F | MDS (RA) | 46, XX | + (2.8 km) | WT | WT | — |
| 78/F | MDS (RAEB) | 46, XX, add(1)(p11), del(11)(q21) | + (1.7 km) | WT | WT | — |
| 80/M | MDS (RAEBt) | 46, XY | + (0.8 km) | WT | WT | — |
| 70/M | MDS (RAEBt) | 46, XY | + (2.0 km) | WT | WT | — |
| 69/M | MDS (RAEBt) | 46, XY | + (1.5 km) | WT | WT | — |
| 80/M | MDS (RAEBt) | 46, XY | −* | 316_338dup | Tyr113Ter | 7 |
| 43/F | MDS (RAEBt) | 45, XX, −7 | − | 511G>A | Asp171Asn | 8 |
— indicates case number was not provided; WT, wild type.
This patient had a past history of manufacturing the poison gas (Mustard gas) during World War II.