CD437-mediated apotosis of B-CLL cells
| . | Apoptosis, % . | |
|---|---|---|
| Control . | CD437 . | |
| Day 3 | 7.3 ± 0.6 | 18.0 ± 1.0 |
| Day 5 | 20.7 ± 0.6 | 34.6 ± 1.5 |
| Day 7 | 29.7 ± 0.6 | 55.7 ± 3.2 |
| . | Apoptosis, % . | |
|---|---|---|
| Control . | CD437 . | |
| Day 3 | 7.3 ± 0.6 | 18.0 ± 1.0 |
| Day 5 | 20.7 ± 0.6 | 34.6 ± 1.5 |
| Day 7 | 29.7 ± 0.6 | 55.7 ± 3.2 |
B-CLL samples were isolated from patients as described in “Materials and methods” and represented greater than 95% B-CLL cells. Samples were exposed to 4 μM CD437 for varying periods, and apoptosis was assessed by acridine orange staining as described in “Materials and methods.” The results represent the mean ± standard deviation of 3 independent determinations.