Table 2. Risk of progression as... | American Society of Hematology

Table 2.

Risk of progression as progression-free survival

Variable	Cutoff	Relative risk (95% CI)	P
Variable	Cutoff	Relative risk (95% CI)	Univariate	Multivariate
Age	65 y^*		.86	NA
Sex	M/F		.49	NA
Microvessel area	0.90 (mm² × 10⁻²)^†		.03	NS
Microvessel number	6 (per 12.5 mm² × 10⁻² fields)^†		.83	NA
PB lymphocytes	21.3 (× 10⁹/L)^*		.73	NA
BM histology	Nondiffuse/diffuse		.05	NS
LDH	478 (U/L)^*	3.30 (1.22-8.88)	.01	.002
β₂-m	2.7 (ng/mL)^*	2.57 (0.96-6.8)	.04	.007
Lymphocyte doubling time	12 mo		.006	NS
sVEGF	218 (pg/mL)^*		.04	NS
sFGF-2	36.6 (pg/mL)^*,^‡		.25	NA

Variable	Cutoff	Relative risk (95% CI)	P
Variable	Cutoff	Relative risk (95% CI)	Univariate	Multivariate
Age	65 y^*		.86	NA
Sex	M/F		.49	NA
Microvessel area	0.90 (mm² × 10⁻²)^†		.03	NS
Microvessel number	6 (per 12.5 mm² × 10⁻² fields)^†		.83	NA
PB lymphocytes	21.3 (× 10⁹/L)^*		.73	NA
BM histology	Nondiffuse/diffuse		.05	NS
LDH	478 (U/L)^*	3.30 (1.22-8.88)	.01	.002
β₂-m	2.7 (ng/mL)^*	2.57 (0.96-6.8)	.04	.007
Lymphocyte doubling time	12 mo		.006	NS
sVEGF	218 (pg/mL)^*		.04	NS
sFGF-2	36.6 (pg/mL)^*,^‡		.25	NA

NA indicates not applied; NS, not significant.

The cutoffs are the median (

) or the 75th percentile (

†

‡

The sFGF-2 levels were significantly higher than in controls (median = 2 pg/mL, range = 2-37 pg/mL;P < .00001, Mann-Whitney test). P by the Cox model.

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