Table 4. Potential risks of fetuses with... | American Society of Hematology

Table 4.

Potential risks of fetuses with inherited α-thalassemia syndromes

α-Globin genotypes		Potential risks of fetuses, %
One parent with Hb H disease	α-Globin genotype of the other parent	Hb H disease (--/-α) or (--/α^Thα)	Homozygous α⁰-thalassemia (--/--)
(--/-α) or (--/α^Thα)	(-α/αα) or (α^Thα/αα)	25	Nil
	(-α/-α) or (α^Thα/-α) or (α^Thα/α^Thα)	50	Nil
	(--/αα)	25	25
	(--/-α) or (--/α^Thα)	50	25

α-Globin genotypes		Potential risks of fetuses, %
One parent with Hb H disease	α-Globin genotype of the other parent	Hb H disease (--/-α) or (--/α^Thα)	Homozygous α⁰-thalassemia (--/--)
(--/-α) or (--/α^Thα)	(-α/αα) or (α^Thα/αα)	25	Nil
	(-α/-α) or (α^Thα/-α) or (α^Thα/α^Thα)	50	Nil
	(--/αα)	25	25
	(--/-α) or (--/α^Thα)	50	25