Peripheral blood and bone marrow analysis
| . | WT . | HET . | HZ . |
|---|---|---|---|
| Peripheral blood | |||
| No. of mice | 14 | 19 | 11 |
| WBC (× 106/mL) | 8.59 ± 0.93 | 8.35 ± 0.43 | 7.27 ± 0.66 |
| RBC (× 109/mL) | 9.33 ± 0.67 | 9.05 ± 0.31 | 9.96 ± 0.66 |
| Platelets (× 106/mL) | 566 ± 32 | 610 ± 28 | 561 ± 34 |
| Neutrophils (%) | 7.8 ± 1.0 | 8.1 ± 0.9 | 8.6 ± 1.0 |
| Neutrophils (× 106/mL) | 0.63 ± 0.10 | 0.67 ± 0.07 | 0.58 ± 0.06 |
| Bone marrow | |||
| No. of mice | 5 | 5 | 5 |
| Blasts and promyelocytes (%) | 1.5 ± 0.2 | 1.6 ± 0.3 | 2.4 ± 0.2 |
| Myelocytes (%) | 9.3 ± 1.0 | 8.4 ± 0.4 | 7.8 ± 0.9 |
| Metamyelocytes (%) | 10.2 ± 0.3 | 10.1 ± 0.6 | 9.2 ± 0.9 |
| Bands and neutrophils (%) | 24.0 ± 2.9 | 27.0 ± 4.0 | 22.7 ± 1.0 |
| Eosinophils (%) | 3.5 ± 0.6 | 3.5 ± 0.4 | 3.3 ± 0.5 |
| Erythroid lineage (%) | 36.8 ± 2.4 | 39.0 ± 3.7 | 39.1 ± 1.4 |
| Lymphoid lineage (%) | 14.6 ± 1.5 | 10.6 ± 1.2 | 15.5 ± 1.1 |
| Myeloid-erythroid ratio | 1.2 ± 0.1 | 1.2 ± 0.3 | 1.1 ± 0.1 |
| . | WT . | HET . | HZ . |
|---|---|---|---|
| Peripheral blood | |||
| No. of mice | 14 | 19 | 11 |
| WBC (× 106/mL) | 8.59 ± 0.93 | 8.35 ± 0.43 | 7.27 ± 0.66 |
| RBC (× 109/mL) | 9.33 ± 0.67 | 9.05 ± 0.31 | 9.96 ± 0.66 |
| Platelets (× 106/mL) | 566 ± 32 | 610 ± 28 | 561 ± 34 |
| Neutrophils (%) | 7.8 ± 1.0 | 8.1 ± 0.9 | 8.6 ± 1.0 |
| Neutrophils (× 106/mL) | 0.63 ± 0.10 | 0.67 ± 0.07 | 0.58 ± 0.06 |
| Bone marrow | |||
| No. of mice | 5 | 5 | 5 |
| Blasts and promyelocytes (%) | 1.5 ± 0.2 | 1.6 ± 0.3 | 2.4 ± 0.2 |
| Myelocytes (%) | 9.3 ± 1.0 | 8.4 ± 0.4 | 7.8 ± 0.9 |
| Metamyelocytes (%) | 10.2 ± 0.3 | 10.1 ± 0.6 | 9.2 ± 0.9 |
| Bands and neutrophils (%) | 24.0 ± 2.9 | 27.0 ± 4.0 | 22.7 ± 1.0 |
| Eosinophils (%) | 3.5 ± 0.6 | 3.5 ± 0.4 | 3.3 ± 0.5 |
| Erythroid lineage (%) | 36.8 ± 2.4 | 39.0 ± 3.7 | 39.1 ± 1.4 |
| Lymphoid lineage (%) | 14.6 ± 1.5 | 10.6 ± 1.2 | 15.5 ± 1.1 |
| Myeloid-erythroid ratio | 1.2 ± 0.1 | 1.2 ± 0.3 | 1.1 ± 0.1 |
Mice were analyzed at 4 to 6 weeks of age. Peripheral blood differentials are based on 200 cell counts.
Bone marrow differentials are based on 500 cell counts. Data represent the mean ± SEM.
HET indicates heterozygous; HZ, homozygous; WT, wild-type.