Table 3.

Prognostic value of the MRC and current risk classifications, P (relative risk, 95% confidence interval)

EFSDFSSurvival
MRC classification3-150    
 Univariate analysis (n = 120 patients) < .001 .02 < .001 
 Multivariate analysis (n = 119 patients)    
  MRC classification < .001 .10 < .001  
  CEBPAmutation .04 (0.47, 0.23-0.97) .05 (0.43, 0.19-0.99) .05 (0.45, 0.21-0.98)  
  FLT3/ITD .32 .50 .07 (1.58, 0.96-2.58)  
Current classification3-150    
 Univariate analysis (n = 119 patients) < .001 .004 < .001  
 Multivariate analysis (n = 119 patients)    
  Current classification < .001 .05 < .001  
  CEBPAmutation .84 .41 .72 
  FLT3/ITD .55 .64 .18 
EFSDFSSurvival
MRC classification3-150    
 Univariate analysis (n = 120 patients) < .001 .02 < .001 
 Multivariate analysis (n = 119 patients)    
  MRC classification < .001 .10 < .001  
  CEBPAmutation .04 (0.47, 0.23-0.97) .05 (0.43, 0.19-0.99) .05 (0.45, 0.21-0.98)  
  FLT3/ITD .32 .50 .07 (1.58, 0.96-2.58)  
Current classification3-150    
 Univariate analysis (n = 119 patients) < .001 .004 < .001  
 Multivariate analysis (n = 119 patients)    
  Current classification < .001 .05 < .001  
  CEBPAmutation .84 .41 .72 
  FLT3/ITD .55 .64 .18 

All patients allografted in CR1 were censored at transplantation time.

F3-150

Risk category definitions are given in Table 4.

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