Table 3. Pharmacokinetics of H22xKi-4... | American Society of Hematology

Table 3.

Pharmacokinetics of H22xKi-4 (dose cohort 20 mg/m²/d, first cycle, n = 6)

	T_max, h	C_max, mg/L	T_1/2 elimination, h	AUCinf, mg × h/L	Vdz, L/m²	Cl, L/h/m²	MRT, h
Day 1
Mean^3-150	4.0	0.63	11.2	10.71	53.17	3.91	16.5
SD		0.32	4.8	6.62	63.94	5.04	6.6
Day 3
Mean^3-150	4.0	0.75	11.5	15.26	27.56	2.08	16.8
SD		0.24	4.3	10.39	13.04	1.61	5.9
Day 5
Mean^3-150	4.0	0.85	10.5	14.71	23.22	2.00	15.4
SD		0.25	5.9	10.65	6.97	1.12	8.5
Day 7
Mean^3-150	4.0	1.1	10.5	18.33	18.11	1.46	15.3
SD		0.4	6.2	11.92	6.33	0.69	8.7

	T_max, h	C_max, mg/L	T_1/2 elimination, h	AUCinf, mg × h/L	Vdz, L/m²	Cl, L/h/m²	MRT, h
Day 1
Mean^3-150	4.0	0.63	11.2	10.71	53.17	3.91	16.5
SD		0.32	4.8	6.62	63.94	5.04	6.6
Day 3
Mean^3-150	4.0	0.75	11.5	15.26	27.56	2.08	16.8
SD		0.24	4.3	10.39	13.04	1.61	5.9
Day 5
Mean^3-150	4.0	0.85	10.5	14.71	23.22	2.00	15.4
SD		0.25	5.9	10.65	6.97	1.12	8.5
Day 7
Mean^3-150	4.0	1.1	10.5	18.33	18.11	1.46	15.3
SD		0.4	6.2	11.92	6.33	0.69	8.7

AUCinf indicates AUC(0-infinity).

Median for T_max.