Cytotoxic deficiency types in patients with HLH
| No. HLH patients . | Type 1 . | Type 2 . | Type 3 . | Type 4 . |
|---|---|---|---|---|
| Non-Turkish white | 16 | 3 | 18 | 6 |
| Turkish | 4 | 1 | 10* | 1 |
| Other ethnic groups | 1 | 1 | 3 | 1 |
| Total | 21 | 5 | 31 | 8 |
| No. HLH patients . | Type 1 . | Type 2 . | Type 3 . | Type 4 . |
|---|---|---|---|---|
| Non-Turkish white | 16 | 3 | 18 | 6 |
| Turkish | 4 | 1 | 10* | 1 |
| Other ethnic groups | 1 | 1 | 3 | 1 |
| Total | 21 | 5 | 31 | 8 |
Patient totals were as follows: Non-Turkish white, 43; Turkish, 16; other ethnic groups, 6; total, 65.
Four patients had the homozygous perforin stop mutation at amino acid (aa) position 374 of the perforin gene.