Remission-induction results
| . | Group 1 n = 102 . | Group 2 n = 160 . | Group 1 vs group 2 . | Group 2A (n = 106) . | Group 2B (n = 53) . | Group 2A vs group 2B . |
|---|---|---|---|---|---|---|
| . | . | |||||
| n (%) . | n (%) . | P . | n (%) . | n (%) . | P . | |
| CR | 84 (82.4) | 135 (84.4) | .67 | 87 (82.1) | 48 (90.1) | .16 |
| CR delayed | 13 (12.7) | 11 (6.9) | .11 | 9 (8.5) | 2 (3.8) | .27 |
| Total CR | 97 (95.1) | 146 (91.2) | .11 | 96 (90.6) | 50 (94.3) | .41 |
| Failure to remit | 3 (2.9) | 5 (3.1) | .93 | 4 (3.8) | 1 (1.8) | .52 |
| Deaths | 2 (2.0) | 8 (5.0) | .21 | 6 (5.6) | 1 (1.8) | .28 |
| Time between courses 1 and 2 (d) | 23.5 | 23 | .44 | 23 | 24 | .39 |
| Ara-C total dose | ||||||
| 12 g/m2 | 79 (75.5) | 127 (79.4) | .73 | 82 (77.4) | 45 (84.9) | .27 |
| 30 g/m2 | 19 (18.6) | 24 (15.0) | .44 | 19 (17.9) | 5 (9.4) | .16 |
| . | Group 1 n = 102 . | Group 2 n = 160 . | Group 1 vs group 2 . | Group 2A (n = 106) . | Group 2B (n = 53) . | Group 2A vs group 2B . |
|---|---|---|---|---|---|---|
| . | . | |||||
| n (%) . | n (%) . | P . | n (%) . | n (%) . | P . | |
| CR | 84 (82.4) | 135 (84.4) | .67 | 87 (82.1) | 48 (90.1) | .16 |
| CR delayed | 13 (12.7) | 11 (6.9) | .11 | 9 (8.5) | 2 (3.8) | .27 |
| Total CR | 97 (95.1) | 146 (91.2) | .11 | 96 (90.6) | 50 (94.3) | .41 |
| Failure to remit | 3 (2.9) | 5 (3.1) | .93 | 4 (3.8) | 1 (1.8) | .52 |
| Deaths | 2 (2.0) | 8 (5.0) | .21 | 6 (5.6) | 1 (1.8) | .28 |
| Time between courses 1 and 2 (d) | 23.5 | 23 | .44 | 23 | 24 | .39 |
| Ara-C total dose | ||||||
| 12 g/m2 | 79 (75.5) | 127 (79.4) | .73 | 82 (77.4) | 45 (84.9) | .27 |
| 30 g/m2 | 19 (18.6) | 24 (15.0) | .44 | 19 (17.9) | 5 (9.4) | .16 |
Group 1, daunorubicin; group 2, idarubicin; group 2A, 10 mg/m2 idarubicin; group 2B, 12 g/m2idarubicin.
12 g/m2 represents total dose received during course 2 with drug delivered as 3 consecutive days of 2 g/m2 twice daily intravenously; 30 g/m2 represents total dose received during course 2 with drug delivered as 5 consecutive days of 3 g/m2 twice daily intravenously.
CR delayed indicates complete remission achieved after course.