Multivariate analysis
| . | . | Resistance to induction . | Overall survival . | ||||
|---|---|---|---|---|---|---|---|
| OR . | 95% CI . | P . | HR . | 95% CI . | P . | ||
| GSTM1/GSTT1 | Any deletion vs normal | 4.7 | 1.2-18.1 | .02 | 2.4 | 1.2-4.9 | .02 |
| Age, y | ≥60 vs ≤59 | .1 | 3 | 1.5-6.3 | .002 | ||
| Karyotype | Favorable vs intermediate vs unfavorable | 5 | 1.6-15.8 | .005 | 2.5 | 1.4-4.4 | .001 |
| All variables | .001 | .0001 | |||||
| . | . | Resistance to induction . | Overall survival . | ||||
|---|---|---|---|---|---|---|---|
| OR . | 95% CI . | P . | HR . | 95% CI . | P . | ||
| GSTM1/GSTT1 | Any deletion vs normal | 4.7 | 1.2-18.1 | .02 | 2.4 | 1.2-4.9 | .02 |
| Age, y | ≥60 vs ≤59 | .1 | 3 | 1.5-6.3 | .002 | ||
| Karyotype | Favorable vs intermediate vs unfavorable | 5 | 1.6-15.8 | .005 | 2.5 | 1.4-4.4 | .001 |
| All variables | .001 | .0001 | |||||
Cytogenetic risk groups were defined according to Grimwade et al17 (see “Patients, materials, and methods”).