Prevalence of VCAM1 promoter and nonsynonymous coding SNPs in stroke and control sickle cell populations in Jamaica
| VCAM1 SNP and genotype . | Stroke (%) n = 51 . | Controls (%) n = 51 . | P for genotype4-150 . |
|---|---|---|---|
| C−2021T4-151 | |||
| CC | 23 (46) | 22 (44) | 1.00 |
| CT | 22 (44) | 20 (40) | .84 |
| TT | 5 (10) | 8 (16) | .56 |
| T−1599G | |||
| TT | 43 (84) | 48 (94) | .20 |
| TG | 8 (16) | 3 (6) | .20 |
| GG | 0 (0) | 0 (0) | NA |
| T−1592C | |||
| TT | 40 (78) | 35 (69) | .26 |
| CT | 8 (16) | 13 (25) | .22 |
| CC | 3 (6) | 3 (6) | .67 |
| T−833C4-151 | |||
| TT | 34 (68) | 33 (66) | 1.00 |
| TC | 13 (26) | 16 (32) | .66 |
| CC | 3 (6) | 1 (2) | .62 |
| C953T/A1150G‡ | |||
| CC/AA | 48 (96) | 47 (96) | 1.00 |
| CT/AG | 2 (4) | 2 (4) | 1.00 |
| TT/GG | 0 (0) | 0 (0) | NA |
| G1238C | |||
| GG | 43 (84) | 34 (67) | .04 |
| GC | 8 (16) | 14 (27) | .15 |
| CC | 0 (0) | 3 (6) | .24 |
| A2146T4-153 | |||
| AA | 45 (88) | 46 (92) | .74 |
| AT | 6 (12) | 3 (6) | .49 |
| TT | 0 (0) | 1 (2) | .50 |
| VCAM1 SNP and genotype . | Stroke (%) n = 51 . | Controls (%) n = 51 . | P for genotype4-150 . |
|---|---|---|---|
| C−2021T4-151 | |||
| CC | 23 (46) | 22 (44) | 1.00 |
| CT | 22 (44) | 20 (40) | .84 |
| TT | 5 (10) | 8 (16) | .56 |
| T−1599G | |||
| TT | 43 (84) | 48 (94) | .20 |
| TG | 8 (16) | 3 (6) | .20 |
| GG | 0 (0) | 0 (0) | NA |
| T−1592C | |||
| TT | 40 (78) | 35 (69) | .26 |
| CT | 8 (16) | 13 (25) | .22 |
| CC | 3 (6) | 3 (6) | .67 |
| T−833C4-151 | |||
| TT | 34 (68) | 33 (66) | 1.00 |
| TC | 13 (26) | 16 (32) | .66 |
| CC | 3 (6) | 1 (2) | .62 |
| C953T/A1150G‡ | |||
| CC/AA | 48 (96) | 47 (96) | 1.00 |
| CT/AG | 2 (4) | 2 (4) | 1.00 |
| TT/GG | 0 (0) | 0 (0) | NA |
| G1238C | |||
| GG | 43 (84) | 34 (67) | .04 |
| GC | 8 (16) | 14 (27) | .15 |
| CC | 0 (0) | 3 (6) | .24 |
| A2146T4-153 | |||
| AA | 45 (88) | 46 (92) | .74 |
| AT | 6 (12) | 3 (6) | .49 |
| TT | 0 (0) | 1 (2) | .50 |
NA indicates not applicable.
2 × 2 tables (Fisher exact test) for indicated genotype versus all others.
There were 2 PCR reactions (1 case and 1 control) that failed to amplify.
There were 1 case and 2 control PCR reactions that failed to amplify.
There was 1 control PCR reaction that failed to amplify.