Frequencies of selected VCAM1 SNPs in African Americans
| VCAM1 region . | Nucleotide position . | Major allele frequency (95% CI) . |
|---|---|---|
| 5′ upstream | C−2021T | 0.59 (0.54-0.64) |
| T−1599G | 0.94 (0.92-0.96) | |
| T−1592C | 0.84 (0.81-0.87) | |
| T−1379C | 0.98 (0.97-0.99) | |
| A−1356G | 0.98 (0.97-0.99) | |
| A−1242T | 0.99 (0.98-1.00)* | |
| G−1148A | 0.98 (0.97-0.99) | |
| T−833C | 0.85 (0.82-0.88) | |
| 5′ UTR, exon 1 | C−109T | 0.90 (0.87-0.93) |
| 5′ UTR, exon 1 | G−54A | 0.90 (0.87-0.93) |
| Coding | ||
| Ig domain 4, exon 5 | C953T | 0.96 (0.94-0.99) |
| Ig domain 4, exon 5 | A1150G | 0.96 (0.94-0.99) |
| Ig domain 5, exon 6 | G1238C | 0.90 (0.87-0.93) |
| TMD, exon 9 | C2079T | 0.82 (0.78-0.86) |
| TMD, exon 9 | A2146T | 0.93 (0.91-0.95) |
| TMD, exon 9 | A2208G | 0.76 (0.74-0.78) |
| VCAM1 region . | Nucleotide position . | Major allele frequency (95% CI) . |
|---|---|---|
| 5′ upstream | C−2021T | 0.59 (0.54-0.64) |
| T−1599G | 0.94 (0.92-0.96) | |
| T−1592C | 0.84 (0.81-0.87) | |
| T−1379C | 0.98 (0.97-0.99) | |
| A−1356G | 0.98 (0.97-0.99) | |
| A−1242T | 0.99 (0.98-1.00)* | |
| G−1148A | 0.98 (0.97-0.99) | |
| T−833C | 0.85 (0.82-0.88) | |
| 5′ UTR, exon 1 | C−109T | 0.90 (0.87-0.93) |
| 5′ UTR, exon 1 | G−54A | 0.90 (0.87-0.93) |
| Coding | ||
| Ig domain 4, exon 5 | C953T | 0.96 (0.94-0.99) |
| Ig domain 4, exon 5 | A1150G | 0.96 (0.94-0.99) |
| Ig domain 5, exon 6 | G1238C | 0.90 (0.87-0.93) |
| TMD, exon 9 | C2079T | 0.82 (0.78-0.86) |
| TMD, exon 9 | A2146T | 0.93 (0.91-0.95) |
| TMD, exon 9 | A2208G | 0.76 (0.74-0.78) |
Based on successfully genotyping 96% to 100% of samples in duplicate for a population of 230 healthy African American donors. 95% CI calculated according to the following formula: q − 2s to q + 2s, where the standard deviation is s =, q is the major allele frequency, and n is the number of chromosomes successfully genotyped.
The CI for A-1242T suggests that the variant allele may be rare; present at a frequency of less than 1%.