Table 5. CsA results in a more profound... | American Society of Hematology

Table 5.

CsA results in a more profound reduction in thymocyte numbers in anti-CD40L mAb-treated mice more than sirolimus or tacrolimus

Group	Total no.	CD4 SP	CD8 SP	DP	DN
Non-BMT controls	85.3 ± 16.2	4.6 ± 0.6	1.1 ± 0.2	71.3 ± 15.2	8.5 ± 2.1
Hamster IgG	55.8 ± 27.9	2.0 ± 1.2	0.6 ± 0.3	48.1 ± 23.1	5.2 ± 3.6
Anti-CD40L	91.5 ± 19.2	3.5 ± 0.8	0.8 ± 0.4	73.6 ± 12.5	13.7 ± 7.3
Anti-CD40L + sirolimus	35.7 ± 6.3^5-151	1.3 ± 0.5^5-151	0.5 ± 0.2	27.6 ± 4.6^5-151	6.3 ± 1.5
Anti-CD40L + CsA	15.4 ± 4.1^5-150,^5-151	0.4 ± 0.1^5-151	0.2 ± 0.2^5-151	11.3 ± 3.1^5-150,^5-151	3.4 ± 1.2
Anti-CD40L + tacrolimus	25.4 ± 2.4^5-151	0.6 ± 0.1^5-151	0.3 ± 0.1^5-151	17.8 ± 6.7^5-151	6.7 ± 4.8

Group	Total no.	CD4 SP	CD8 SP	DP	DN
Non-BMT controls	85.3 ± 16.2	4.6 ± 0.6	1.1 ± 0.2	71.3 ± 15.2	8.5 ± 2.1
Hamster IgG	55.8 ± 27.9	2.0 ± 1.2	0.6 ± 0.3	48.1 ± 23.1	5.2 ± 3.6
Anti-CD40L	91.5 ± 19.2	3.5 ± 0.8	0.8 ± 0.4	73.6 ± 12.5	13.7 ± 7.3
Anti-CD40L + sirolimus	35.7 ± 6.3^5-151	1.3 ± 0.5^5-151	0.5 ± 0.2	27.6 ± 4.6^5-151	6.3 ± 1.5
Anti-CD40L + CsA	15.4 ± 4.1^5-150,^5-151	0.4 ± 0.1^5-151	0.2 ± 0.2^5-151	11.3 ± 3.1^5-150,^5-151	3.4 ± 1.2
Anti-CD40L + tacrolimus	25.4 ± 2.4^5-151	0.6 ± 0.1^5-151	0.3 ± 0.1^5-151	17.8 ± 6.7^5-151	6.7 ± 4.8

B6 mice were irradiated with 200 cGy TBI on day − 1 and infused with 40 × 10⁶ BALB/c BM on day 0. Reagents were administered from day − 1 through day + 6. Thymus counts and phenotype were evaluated on day 7 after BMT. Shown are absolute numbers (× 10⁶). n = 4/group. SP indicates single positive; DP, double positive; DN, double negative.

F5-150

P ≤ .05 compared with hamster IgG.

F5-151

P ≤ .05 compared with anti-CD40L mAb as a single agent.

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